Results 61 to 70 of about 115,303,296 (139)

Perineurial Barrier Glia Physically Respond to Alcohol in an Akap200-Dependent Manner to Promote Tolerance

Cell Reports, 2018
Summary: Ethanol is the most common drug of abuse. It exerts its behavioral effects by acting on widespread neural circuits; however, its impact on glial cells is less understood.
Sarah J. Parkhurst, Pratik Adhikari, Jovana S. Navarrete, Arièle Legendre, Miguel Manansala, Fred W. Wolf   +5 more
doaj   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Cell Reports, 2017
Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo, Wei-Hong Xiong, Maho Takahashi, Sheng Miao, Adriana L. Andrade, Dale A. Fortin, Guang Yang, Maozhen Qin, Barbara F. Smoody, Philip J.S. Stork, Haining Zhong   +10 more
doaj   +1 more source

RACK(1) to the future – a historical perspective [PDF]

, 2013
This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as ...
Kiely, Patrick, Ron, D., George S Baillie, Baillie, George S., David R. Adams (2135944), Adams, Dave, O’Connor, Rosemary, Adams, David, Baillie, G.S., O'Connor, R, Dorit Ron, Long, Aideen, Rosemary O’Connor, George S. Baillie (2200696), Adams, David R, Adams, DR, Ron, Dorit, Kiely, PA, Kiely, Patrick A, OConnor, Rosemary, Adams, David R., Adams, D.R., Baillie, GS, Patrick A. Kiely (12579106), O'Connor, Rosemary, Dorit Ron (741576), David R Adams, Long, A, Baillie, George, Aideen Long (2238037), Baillie, George S, O\u27Connor, Rosemary, Kiely, Patrick A., Patrick A Kiely, O’Connor, R., Kiely, P.A., Aideen Long, Long, A.   +37 more
core   +1 more source

Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase

, 2007
Kinase anchoring proteins (AKAPs) are a family of structurally diverse multidomain proteins classified solely by their ability to bind cAMP-dependent protein kinase/protein kinase A (PKA).
Alison Jane Davis (7656008)
core   +6 more sources

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

BMC Cell Biology, 2011
Background Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA).
Riedemann Johann, Mouton Jomien, Korkie Lundi J, Kinnear Craig J, Loos Benjamin, Ramburan Amsha, Uys Gerrida M, Moolman-Smook Johanna C   +7 more
doaj   +1 more source

Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. [PDF]

PLoS ONE, 2011
Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for ...
Andrew J McKenzie, Shirley L Campbell, Alan K Howe   +2 more
doaj   +1 more source

A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy [PDF]

, 2013
In response to stress, the heart undergoes a remodeling process associated with cardiac hypertrophy that eventually leads to heart failure. A-kinase anchoring proteins (AKAPs) have been shown to coordinate numerous prohypertrophic signaling pathways in ...
Cariolato, Luca, Diviani, Dario, Pérez López, Irene, I. Perez Lopez, D. Maric, D. Diviani, Maric, Darko, H. Abriel, Gillet, Ludovic, L. Cariolato, Abriel, Hugues, L. Gillet   +11 more
core   +1 more source

Subcellular location of PKA controls striatal plasticity: stochastic simulations in spiny dendrites. [PDF]

PLoS Computational Biology, 2012
Dopamine release in the striatum has been implicated in various forms of reward dependent learning. Dopamine leads to production of cAMP and activation of protein kinase A (PKA), which are involved in striatal synaptic plasticity and learning.
Rodrigo F Oliveira, Rodrigo F Oliveira, Myungsook Kim, Kim T Blackwell   +3 more
doaj   +1 more source

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]

, 2014
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen, Hukelmann, Jens L., Cantrell, Doreen A., Navarro, Maria N.   +3 more
core   +1 more source