Results 11 to 20 of about 38,040 (251)
A-kinase anchoring protein–mediated compartmentalization of pro-survival signaling in the retina [PDF]
Neural Regeneration ResearchJoanna Mackiewicz, Tomasz Boczek
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Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction
Cells, 2021 Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation to various extracellular stimuli.
Anne-Sophie Colombe, Guillaume Pidoux
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Function, 2022 β-adrenergic receptor (β-AR) signaling in cardiac myocytes is central to cardiac function, but spatiotemporal activation within myocytes is unresolved. In rabbit ventricular myocytes, β-AR agonists or high extracellular [Ca] were applied locally at one ...
Thomas R Shannon +9 more
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A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling
Cells, 2023 The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper ...
Hariharan Subramanian +1 more
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A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2004 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
Lorene K, Langeberg, John D, Scott
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Protein Kinase A Anchoring [PDF]
Journal of Biological Chemistry, 1997 Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
M L, Dell'Acqua, J D, Scott
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AKAP79 enables calcineurin to directly suppress protein kinase A activity
eLife, 2021 Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA).
Timothy W Church +7 more
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A-Kinase Anchoring Proteins [PDF]
Circulation, 2010 The heart is a sophisticated organ that continuously pumps blood to ensure that oxygen and nutrients reach the brain, other organs, and peripheral tissue. The right side of the heart pumps blood to the lungs, where oxygen is taken up and carbon dioxide is removed.
John D, Scott, Luis F, Santana
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Defining A‐Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA‐RI) [PDF]
ChemBioChem, 2016 Eileen J Kennedy +2 more
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A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors [PDF]
Journal of Biological Chemistry, 2015 Patrick Nygren +2 more
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