Results 11 to 20 of about 72,712 (256)
A-Kinase Anchoring Protein Targeting of Protein Kinase A and Regulation of HERG Channels [PDF]
Journal of Membrane Biology, 2008 Adrenergic stimulation of the heart initiates a signaling cascade in cardiac myocytes that increases the concentration of cAMP. Although cAMP elevation may occur over a large area of a target-organ cell, its effects are often more restricted due to local concentration of its main effector, protein kinase A (PKA), through A-kinase anchoring proteins ...
Yan Li +3 more
core +4 more sources
Cypher/ZASP is a novel A-kinase anchoring protein. [PDF]
J Biol Chem, 2013 PKA signaling is important for the post-translational modification of proteins, especially those in cardiomyocytes involved in cardiac excitation-contraction coupling. PKA activity is spatially and temporally regulated through compartmentalization by protein kinase A anchoring proteins.
Lin C +13 more
europepmc +6 more sources
A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction [PDF]
Cells, 2021 Darko Maric +2 more
exaly +2 more sources
A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2004 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
Lorene K, Langeberg, John D, Scott
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Protein Kinase A Anchoring [PDF]
Journal of Biological Chemistry, 1997 Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
M L, Dell'Acqua, J D, Scott
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A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection [PDF]
Journal of Cardiovascular Development and Disease, 2018 Dario Diviani
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A-Kinase Anchoring Proteins [PDF]
Circulation, 2010 The heart is a sophisticated organ that continuously pumps blood to ensure that oxygen and nutrients reach the brain, other organs, and peripheral tissue. The right side of the heart pumps blood to the lungs, where oxygen is taken up and carbon dioxide is removed.
John D, Scott, Luis F, Santana
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Defining A‐Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA‐RI) [PDF]
ChemBioChem, 2016 Daniela Bertinetti +2 more
exaly +2 more sources
A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors [PDF]
Journal of Biological Chemistry, 2015 Jennifer L Whiting +2 more
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A-kinase anchoring proteins take shape [PDF]
Current Opinion in Cell Biology, 2007 A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates.
Darren L, Beene, John D, Scott
openaire +2 more sources