Results 11 to 20 of about 115,303,296 (139)

A-kinase anchoring protein–mediated compartmentalization of pro-survival signaling in the retina [PDF]

Neural Regeneration Research
Joanna Mackiewicz, Tomasz Boczek
doaj   +2 more sources

Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction

Cells, 2021
Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation to various extracellular stimuli.
Anne-Sophie Colombe, Guillaume Pidoux
doaj   +1 more source

Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7

Function, 2022
β-adrenergic receptor (β-AR) signaling in cardiac myocytes is central to cardiac function, but spatiotemporal activation within myocytes is unresolved. In rabbit ventricular myocytes, β-AR agonists or high extracellular [Ca] were applied locally at one ...
Thomas R Shannon, Dan J Bare, Sabine Van Dijk, Shayan Raofi, Tiffany N-M Huynh, Yang K Xiang, Julie Bossuyt, Kimberly L Dodge-Kafka, Kenneth S Ginsburg, Donald M Bers   +9 more
doaj   +1 more source

A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling

Cells, 2023
The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper ...
Hariharan Subramanian, Viacheslav O. Nikolaev   +1 more
doaj   +1 more source

AKAP79 enables calcineurin to directly suppress protein kinase A activity

eLife, 2021
Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA).
Timothy W Church, Parul Tewatia, Saad Hannan, João Antunes, Olivia Eriksson, Trevor G Smart, Jeanette Hellgren Kotaleski, Matthew G Gold   +7 more
doaj   +1 more source

Interacting protein kinases involved in the regulation of flagellar length [PDF]

, 2006
A striking difference of the life stages of the protozoan parasite Leishmania is a long flagellum in the insect stage promastigotes and a rudimentary organelle in the mammalian amastigotes.
Scholz, M., Melzer, I.M., Erdmann, M., Schmetz, C., Wiese, M.   +4 more
core   +4 more sources

Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI). [PDF]

Chembiochem, 2016
Autenrieth K, Bendzunas NG, Bertinetti D, Herberg FW, Kennedy EJ.   +4 more
europepmc   +2 more sources

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. [PDF]

J Biol Chem, 2015
Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD.   +9 more
europepmc   +2 more sources

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein. [PDF]

Biochim Biophys Acta, 2015
Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW.   +9 more
europepmc   +2 more sources

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]

, 2014
Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf, Solyakov, Lev, Doerig, Christian, Graciotti, Michele, Burley, Glenn, Tobin, Andrew B, Cullis, Paul, Alam, Mahmood, Bottrill, Andrew R   +8 more
core   +3 more sources