Results 21 to 30 of about 38,040 (251)
A-kinase anchoring proteins take shape [PDF]
Current Opinion in Cell Biology, 2007 A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates.
Darren L, Beene, John D, Scott
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Anchoring proteins encounter mitotic kinases [PDF]
Cell Cycle, 2013 Defective progression of cells through mitosis permits an accumulation of genetic defects that lead to aneuploidy. Cells in a state of aneuploidy acquire mutations that eventually cause their transformation from normal cells into cancer.1 Recent evidence suggests that perturbing the spatial and temporal pattern of cell division can enhance such ...
Canton, David A., Scott, John D.
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Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Dissemination of chemical information throughout the cell is a fundamental biological process with clinical relevance. Pathological changes in local signaling enzyme activity are linked to diseases, including schizophrenia, Alzheimer’s disease, cardiac arrhythmias, and seizures.
F. Donelson Smith +14 more
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Journal of Pharmacological Sciences, 2008 In our previous study, anti-apoptotic effects of GABAC-receptor stimulation was suppressed by inhibitors of cAMP-dependent protein kinase (PKA), implying GABACreceptor–mediated PKA activation. The present study showed that GABAC-receptor stimulation with
Li Yang +4 more
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Endokrynologia Polska, 2020 INTRODUCTION: At present, the number of people suffering from diabetes and obesity is increasing in China, and also all over the world. Researchers found that decreased expression of A-kinase anchoring protein 1 (AKAP1), which was thought to regulate the
Haifeng Zhu, Xingbo Cheng, Qingtao Fan
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Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]
PLoS Computational Biology, 2011 The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim +8 more
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Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Frontiers in Pharmacology, 2015 Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a wide variety of cellular processes, a majority of which act through the cAMP - protein kinase A (PKA) signalling pathway and involve PKA phosphorylation of specific
Ana Isabel C. Calejo, Kjetil eTaskén
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Frontiers in Pharmacology, 2015 Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren +3 more
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Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220 [PDF]
Journal of Biological Chemistry, 2015 Ole-Morten Seternes +2 more
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Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System
Journal of Cardiovascular Development and Disease, 2018 A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases.
Santosh V. Suryavanshi +2 more
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