Results 161 to 170 of about 2,191,855 (361)

Chrysin 7‐ O ‐β‐ d ‐glucopyranoside increases hepatic low‐density lipoprotein receptor expression through AMP ‐activated protein kinase activation [PDF]

, 2023
Naoki Kaname, Takahiro Fujimaki, Shotaro Horikoshi, K. Fujimura, Manami Kodaka, Shinnosuke Wakamori, Ryo Katsuta, Ken Ishigami, Tsukasa Suzuki, Yuji Yamamoto, Jun Inoue   +10 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Exploring the differential localization of protein kinase A isoforms in Candida albicans

mSphere
The cAMP-dependent protein kinase A (PKA) plays important roles in a wide range of biological processes in eukaryotic organisms. In the fungal pathogen Candida albicans, PKA is a critical regulator of morphological transitions, which are a key virulence ...
Saif Hossain, Zhongle Liu, Nicole Robbins, Leah E. Cowen   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

, 2020
Guillaume Beauclair, Félix Streicher, Maxime Chazal, Daniela Bruni, Sarah Lesage, Ségolène Gracias, Salomé Bourgeau, Laura Sinigaglia, Takashi Fujita, Éliane Meurs, Frédéric Tangy, Nolwenn Jouvenet   +11 more
openalex   +2 more sources

The CsSTE50 Adaptor Protein in Mitogen-Activated Protein Kinase Cascades Is Essential for Pepper Anthracnose Disease of Colletotrichum scovillei [PDF]

, 2022
Jong‐Hwan Shin, Byung-Seong Park, Kyoung Su Kim   +2 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Participation of cAMP in tacrine-induced gastric smooth muscle relaxation

Open Life Sciences, 2011
Prissadova Natalia, Argirova Mariana, Krastev Athanas, Turiiski Valentin, Ardasheva Rayna   +4 more
doaj   +1 more source

A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases

, 2005
Muh‐Ching Yee, Stefanie C. Fas, Michelle M. Stohlmeyer, Thomas J. Wandless, Karlene A. Cimprich   +4 more
openalex   +1 more source

Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro [PDF]

, 2013
Qin Feng, Xiaojun Gou, Shengxi Meng, Cheng Huang, Yuquan Zhang, Yajun Tang, Wenjing Wang, Lin Xu, Jinghua Peng, Yiyang Hu   +9 more
openalex   +1 more source