Results 11 to 20 of about 2,670,458 (365)
A-kinase-interacting protein localizes protein kinase A in the nucleus. [PDF]
Proceedings of the National Academy of Sciences, 2005 The genetic variability and covalent modifications associated with the amino terminus of the protein kinase A (PKA) catalytic (C) subunit suggest that it may contribute to protein-protein interactions and/or localization.
M. Sastri +3 more
semanticscholar +4 more sources
Protein Kinases in Leukemias [PDF]
Cancers, 2021 Protein kinases (PK) make up around 2% of the human genome and their expression profile varies depending on the organ and tissue [...]
Paulo De Sepulveda, Jean-Max Pasquet
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Protein Kinase A in Cancer [PDF]
Cancers, 2011 In the past, many chromosomal and genetic alterations have been examined as possible causes of cancer. However, some tumors do not display a clear molecular and/or genetic signature. Therefore, other cellular processes may be involved in carcinogenesis.
CARETTA A, MUCIGNAT, CARLA
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Correlation of human protein kinase A (PKA) and G-glycoprotein in patients with T2DM
Medical Journal of Babylon, 2021 Background: Type 2 diabetes usually starts with insulin resistance—a condition that happens when muscle, fat, and liver cells cannot use insulin to deliver glucose into the cells of the body for energy use.
Sura S Khadhim +2 more
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Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase [PDF]
Molecular and Cellular Biology, 1998 Phosphorylation of the catalytic subunit of cyclic AMP-dependent protein kinase, or protein kinase A, on Thr-197 is required for optimal enzyme activity, and enzyme isolated from either animal sources or bacterial expression strains is found phosphorylated at this site.
Robert A. Steinberg +3 more
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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]
Journal of Biological Chemistry, 2005 The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Anthony R. Means +5 more
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Current Biology, 2015 Soppa and Becker introduce the DYRK family of dual specificity protein kinases and their diverse functions and associations with genetic diseases.
Ulf Soppa, Walter Becker
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A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling
Cells, 2023 The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper ...
Hariharan Subramanian +1 more
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A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2004 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
John D. Scott, Lorene K. Langeberg
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A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction
Cells, 2021 Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue.
Darko Maric +5 more
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