Results 31 to 40 of about 2,106,225 (315)
Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]
Scripta Medica, 2023 Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad +4 more
doaj
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus [PDF]
, 1999 Synaptic NMDA-type glutamate receptors are anchored to the second of three PDZ (PSD-95/Discs large/ZO-1) domains in the postsynaptic density (PSD) protein PSD-95.
Apperson, Michelle +3 more
core +1 more source
eLife, 2022 Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture.
Komal Ramani +6 more
doaj +1 more source
Drosophila heat shock response requires the jnk pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif [PDF]
, 2012 Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Garlena, RA, Gonda, RL, Stronach, B
core +5 more sources
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]
Journal of Biological Chemistry, 2005 (R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S. +21 more
openaire +5 more sources
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]
, 2017 c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie +15 more
core +2 more sources
IUBMB Life, 2000 Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
openaire +2 more sources
Biology Open, 2017 Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
doaj +1 more source
Molecules, 2019 Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska +4 more
doaj +1 more source
Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
eLife, 2022 Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial.
Juan Qin +8 more
doaj +1 more source