Results 321 to 330 of about 2,191,855 (361)
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Rottlerin, a Novel Protein Kinase Inhibitor
Biochemical and Biophysical Research Communications, 1994Rottlerin, a compound from Mallotus philippinensis, is shown to inhibit protein kinases with some specificity for PKC. To some extent, the novel inhibitor is able to differentiate between PKC isoenzymes, with IC50 values for PKC delta of 3-6 microM, PKC alpha,beta,gamma of 30-42 microM and PKC epsilon,eta,zeta of 80-100 microM.
M, Gschwendt +6 more
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Protein Kinase A and Chromosomal Stability
Annals of the New York Academy of Sciences, 2002Abstract: All malignant human tumors contain chromosomal rearrangements. Among them, the majority of solid tumors show chromosomal instability, caused by abberations in chromosomal segregation during cell division. Chromosomal instability, defined as increased probability of formation of novel chromosomal mutations compared to that of normal or ...
Ludmila, Matyakhina +2 more
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Protein kinases 1988: a current perspective
The FASEB Journal, 1988This review focuses on several recent developments in the field of protein kinases. In the area of protein serine/threonine kinases, much has been learned recently about protein kinase C structure and function. Novel lipid mediators, both stimulatory and inhibitory, have been discovered, and kinase has been shown to be an ...
P J, Blackshear, A C, Nairn, J F, Kuo
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Science's STKE, 2007
The Yersinia Gram-negative bacteria are pathogenic to humans causing such diseases as bubonic plague. Through the action of a type III protein secretion system, Yersinia injects bacterial proteins necessary to subvert the host cell's normal processes and to promote bacterial survival and replication. Navarro
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The Yersinia Gram-negative bacteria are pathogenic to humans causing such diseases as bubonic plague. Through the action of a type III protein secretion system, Yersinia injects bacterial proteins necessary to subvert the host cell's normal processes and to promote bacterial survival and replication. Navarro
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Mechanisms of Protein Kinase A Anchoring
2010The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA). Due to the ubiquitous nature of the cAMP/PKA system, PKA signaling pathways underlie strict spatial and ...
Philipp, Skroblin +4 more
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British Journal of Pharmacology, 2014
The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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Protein Kinases in Neutrophils: A Review
Membrane Biochemistry, 1989In chemotactic factor-stimulated neutrophils, rapid increases of intracellular levels of cyclic AMP, calcium, and diacylglycerol have been observed and may be linked to protein kinase activation. The study of the physiological role and regulation of protein kinases in the neutrophil and the identification of their substrates has provided valuable ...
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly
The protein corona from nanomedicine to environmental science
Nature Reviews Materials, 2023Assist Prof Morteza Mahmoudi +2 more
exaly