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Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

RIPK3 inhibitor GSK872 targets angiotensin II induced cardiomyocyte hypertrophy by regulating Ca2+/ calmodulin dependent protein kinase II. [PDF]

PLoS One
Zhang J, Yu H, Yang Y, Liu A, Wang P.
europepmc   +1 more source

Retraction: Berberine Chloride Mediates Its Anti-Leishmanial Activity via Differential Regulation of the Mitogen Activated Protein Kinase Pathway in Macrophages. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Small Gold Nanoparticles Alleviate Huntington's Disease via Modulating p38α Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1. [PDF]

ACS Nano
Lee LKC, Leong LI, Shyngys M, Bai Q, Lui YL, Cui C, Liu S, Xiao Y, Chan CKW, Cheung WH, Kwan KM, Chan HYE, Choi CHJ.   +12 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock. [PDF]

J Biol Chem
Hu P, Ji Z, Xiong H, Yu S, Shan X, Dong H, Jing W, Wang J, Wang Z, Cui Y, Wang B, Zhou Y, Li Z, Tang J, Cui Y, Wang T, Xie K, Yu Q.   +17 more
europepmc   +1 more source

Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells. [PDF]

Am J Physiol Cell Physiol
Lone M, Singh P, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E.   +5 more
europepmc   +1 more source

Commentary on "Targeting protein kinase D in oral squamous cell carcinoma: a promising therapeutic approach" by Dandapani. [PDF]

Int J Surg
Sadeghi M, Mehrabkhani M.
europepmc   +1 more source

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Protein Kinase A

Definitions, 2020
Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/T hr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homoor ...
openaire   +2 more sources