Results 31 to 40 of about 2,152,541 (363)

Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

eLife, 2023
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood.
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan   +19 more
doaj   +1 more source

Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]

Scripta Medica, 2023
Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad, Elimban Vijayan, Prasad Jaykishan, Shah Anureet K., Dhalla Naranjan S.   +4 more
doaj  

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

eLife, 2022
Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture.
Komal Ramani, Nirmala Mavila, Aushinie Abeynayake, Maria Lauda Tomasi, Jiaohong Wang, Michitaka Matsuda, Eki Seki   +6 more
doaj   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Proteomic analysis of neonatal mouse hearts shows PKA functions as a cardiomyocyte replication regulator

Proteome Science, 2023
The ability of the adult mammalian heart to regenerate can save the cardiac muscle from a loss of function caused by injury. Cardiomyocyte regeneration is a key aspect of research for the treatment of cardiovascular diseases.
Lizhi Hu, Minglu Liang, Qin Jiang, Youming Jie, Long Chen, Fengxiao Zhang   +5 more
doaj   +1 more source

Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

eLife, 2022
Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial.
Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi   +8 more
doaj   +1 more source

Purification and Characterization of a Chloroplast Outer-Envelope-Bound, ATP-Dependent Protein Kinase [PDF]

, 1988
An ATP-dependent protein kinase was partially purified from isolated outer envelope membranes of pea (Pisum sativum L., Progress No. 9) chloroplasts. The purified kinase had a molecular weight of 70 kilodaltons, as determined by sodium dodecyl sulfate ...
Soll, Jürgen
core   +2 more sources

Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Molecules, 2019
Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska, Justyna Wiśniewska, Łukasz Fałtynowicz, Bruno Lapied, Maria Stankiewicz   +4 more
doaj   +1 more source

cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

eLife, 2023
The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module has a critical role in a presynaptic form of long-term potentiation in
Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying Shen   +14 more
doaj   +1 more source

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source