Results 31 to 40 of about 3,503,537 (407)

Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]

Scripta Medica, 2023
Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad, Elimban Vijayan, Prasad Jaykishan, Shah Anureet K., Dhalla Naranjan S.   +4 more
doaj  

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

Journal of Biological Chemistry, 1998
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements
M. Favata, K. Horiuchi, E. Manos, A. J. Daulerio, Deborah A. Stradley, W. Feeser, Drew E. Van Dyk, W. Pitts, R. Earl, F. Hobbs, R. Copeland, R. Magolda, P. Scherle, J. Trzăskos   +13 more
semanticscholar   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

eLife, 2022
Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial.
Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi   +8 more
doaj   +1 more source

Purification and Characterization of a Chloroplast Outer-Envelope-Bound, ATP-Dependent Protein Kinase [PDF]

, 1988
An ATP-dependent protein kinase was partially purified from isolated outer envelope membranes of pea (Pisum sativum L., Progress No. 9) chloroplasts. The purified kinase had a molecular weight of 70 kilodaltons, as determined by sodium dodecyl sulfate ...
Soll, Jürgen
core   +2 more sources

Cell membrane disruption stimulates cAMP and Ca2+ signaling to potentiate cell membrane resealing in neighboring cells

Biology Open, 2017
Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
doaj   +1 more source

cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

eLife, 2023
The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module has a critical role in a presynaptic form of long-term potentiation in
Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying Shen   +14 more
doaj   +1 more source

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Depletion of Ca2+ from the sarcoplasmic reticulum of cardiac muscle prompts phosphorylation of phospholamban to stimulate store refilling [PDF]

, 1998
Nonmuscle cells have almost ubiquitously evolved a mechanism to detect and prevent Ca(2+) store depletionstore operated calcium entry. No such mechanism has, as yet, been reported in cardiac myocytes.
Bhogal, M.S., Colyer, J.
core   +2 more sources

Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Molecules, 2019
Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska, Justyna Wiśniewska, Łukasz Fałtynowicz, Bruno Lapied, Maria Stankiewicz   +4 more
doaj   +1 more source