Results 41 to 50 of about 1,326,529 (167)

Inhibition of Vascular Smooth Muscle Growth via Signaling Crosstalk between AMP-Activated Protein Kinase and cAMP-Dependent Protein Kinase

Frontiers in Physiology, 2012
Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking.
Joshua Daniel Stone, Avinash eNarine, David Anthony Tulis   +2 more
doaj   +1 more source

AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes

Physiological Reports, 2019
Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR) of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATPase (SERCA2) function, whereas a protein kinase A (PKA)‐dependent ...
Farigol Hakem Zadeh, Allen C. T. Teng, Uros Kuzmanov, Paige J. Chambers, Allan R. Tupling, Anthony O. Gramolini   +5 more
doaj   +1 more source

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +1 more source

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

eLife, 2020
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia   +13 more
doaj   +1 more source

Differential Downregulation of β1‐Adrenergic Receptor Signaling in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart.
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang   +6 more
doaj   +1 more source

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation

Journal of Lipid Research, 2016
The endocannabinoids and their main receptor, cannabinoid type-1 (CB1), suppress intracellular cyclic AMP levels and have emerged as key players in the control of energy metabolism.
Lucia M. Krott, Fabiana Piscitelli, Markus Heine, Simona Borrino, Ludger Scheja, Cristoforo Silvestri, Joerg Heeren, Vincenzo Di Marzo   +7 more
doaj   +1 more source

Allosteric cooperativity in protein kinase A [PDF]

Proceedings of the National Academy of Sciences, 2008
Allosteric signaling in proteins requires long-range communication mediated by highly conserved residues, often triggered by ligand binding. In this article, we map the allosteric network in the catalytic subunit of protein kinase A using NMR spectroscopy.
Larry R, Masterson, Alessandro, Mascioni, Nathaniel J, Traaseth, Susan S, Taylor, Gianluigi, Veglia   +4 more
openaire   +2 more sources

Dynamic architecture of a protein kinase [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Protein kinases represent a critically important family of regulatory enzymes. Their activity can be altered by mutations and binding events distant from the active site. To understand the nature of these long-distance effects, we used microsecond-timescale molecular dynamic simulation to subdivide a prototypical kinase, protein ...
McClendon, Christopher L, Kornev, Alexandr P, Gilson, Michael K, Taylor, Susan S   +3 more
openaire   +4 more sources

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases

Neural Regeneration Research
The interaction between the gut microbiota and cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway in the host’s central nervous system plays a crucial role in neurological diseases and enhances communication along the gut ...
Fengcheng Deng, Dan Yang, Lingxi Qing, Yifei Chen, Jilian Zou, Meiling Jia, Qian Wang, Runda Jiang, Lihua Huang   +8 more
doaj   +1 more source

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Respiratory Research, 2023
Background Diacylglycerol kinase (DGK) regulates intracellular signaling and functions by converting diacylglycerol (DAG) into phosphatidic acid. We previously demonstrated that DGK inhibition attenuates airway smooth muscle (ASM) cell proliferation ...
Miguel A. Hernandez-Lara, Santosh Kumar Yadav, Stanley Conaway, Sushrut D. Shah, Raymond B. Penn, Deepak A. Deshpande   +5 more
doaj   +1 more source