Results 51 to 60 of about 2,152,541 (363)

Protein Kinases and Addiction [PDF]

Annals of the New York Academy of Sciences, 2008
Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug‐induced changes in synaptic plasticity due to alterations in cell signaling, gene transcription, and ...
Robert O. Messing, Anna M. Lee
openaire   +3 more sources

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott, Averous, Avruch, Azoulay-Alfaguter, Bain, Bar-Peled, Bar-Peled, Bradford, Carriere, Carriere, Clare Stretton, Coghlan, Cross, Demetriades, Dibble, Doble, Fonseca, Foster, Frey, Ganley, Garcia-Martinez, Gwinn, Gwinn, Hajduch, Hara, Harinder S. Hundal, Hosokawa, Ian G. Ganley, Inoki, Inoki, Inoki, Jewell, Jung, Kelleher, Kim, Kim, Kwak, Lipina, MacAulay, Marchand, Martina, Meijer, Menon, Michael J. Munson, Oshiro, Oshiro, Parr, Peter M. Taylor, Pfaffl, Ramirez-Valle, Rebsamen, Sancak, Shin, Smith, Stretton, Sutherland, Thorsten M. Hoffmann, Wang, Wang, Yoon, Zoncu   +60 more
core   +3 more sources

Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria [PDF]

, 1985
A series of plasmids containing different segments of the v-abl oncogene have been constructed to express different portions of the v- abl protein in bacteria.
Baltimore, David, Wang, Jean Y. J.
core  

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)

Biology, 2023
Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh, Abigail E. Conklin, Lalima K. Madan   +2 more
doaj   +1 more source

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg, Adams, Alexander, Bardwell, Barsyte-Lovejoy, Bhattacharyya, Bhattacharyya, Buschbeck, Caffrey, Cavanaugh, Chang, Chen, Coulombe, Drew, Emsley, Garai, Guo, Gupta, Gógl, Hayashi, Hu, Jacobs, Kabsch, Kato, Kato, Kondoh, Li, Liu, Liu, Liu, Ma, McCoy, Milanesi, Moscat, Murakami, Nakamura, Nakamura, Nakamura, Nishimoto, Pearson, Piserchio, Potthoff, Raman, Ranganathan, Regan, Reményi, Sharrocks, Sohn, Tanoue, Wang, Watson, Winn, Won, Zarrinpar, Zeke, Zhang, Zhou, Zhou   +57 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The Extract of Humulus japonicus Inhibits Lipogenesis and Promotes Lipolysis via PKA/p38 Signaling

Obesity Facts
Introduction: Previous research has shown that an aqueous extract of Humulus japonicus (EH) can ameliorate hypertension, nonalcoholic fatty liver disease, and oxidative stress in adipocytes by activating the thermogenic pathway.
Jaw Long Sun, Young Jin Kim, Wonjun Cho, Sung Su Park, A.M. Abd El-Aty, Enas H. Mobarak, Tae Woo Jung, Ji Hoon Jeong   +7 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source