Results 1 to 10 of about 2,888,198 (397)
Role of Akt/Protein Kinase B in Cancer Metastasis [PDF]
Biomedicines, 2023 Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies.
Mohammad Islam, Sarah Jones, Ian Ellis
doaj +5 more sources
The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]
Journal of Mind and Medical Sciences, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Daniela Miricescu +8 more
doaj +3 more sources
B-50 Protein Kinase and Kinase C in Rat Brain [PDF]
, 1982 Publisher Summary Adrenocorticotropic hormone ACTH and some of its fragments are known to affect both brain metabolism and behavior. Neurochemical studies have revealed that such peptides can modify RNA and protein metabolism, polyamine metabolism, cyclic nucleotide levels, catecholamine mover, and phosphorylation of both membrane proteins and lipids.
Vincent J. Aloyo, H. Zwiers, W.H. Gispen
openalex +5 more sources
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation [PDF]
Biochemical Journal, 1999 Growth factor induced activation of phosphoinositide 3-kinase and protein kinase B (PKB) leads to increased activity of the mammalian target of rapamycin (mTOR).
B. Nave +4 more
openalex +2 more sources
Indonesian Journal of Pharmacy, 2014 Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/
Tran Phi Hoang Yen +4 more
doaj +4 more sources
Role of Translocation in the Activation and Function of Protein Kinase B [PDF]
Journal of Biological Chemistry, 1997 We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N terminus of protein kinase B to alter its subcellular location.
Andjelković, Mirjana +9 more
openaire +5 more sources
Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells [PDF]
Journal of Biological Chemistry, 1999 Angiotensin II, a hypertrophic/anti-apoptotic hormone, utilizes reactive oxygen species (ROS) as growth-related signaling molecules in vascular smooth muscle cells (VSMCs).
Masuko Ushio‐Fukai +6 more
openalex +2 more sources
Phospho-Form Specific Substrates of Protein Kinase B (AKT1)
Frontiers in Bioengineering and Biotechnology, 2021 Protein kinase B (AKT1) is hyper-activated in diverse human tumors. AKT1 is activated by phosphorylation at two key regulatory sites, Thr308 and Ser473. Active AKT1 phosphorylates many, perhaps hundreds, of downstream cellular targets in the cytosol and ...
McShane McKenna +5 more
doaj +1 more source
Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Glioma is one of the common intracranial malignant tumors, but the specific mechanism was unclear. The expression level of choline kinase A (CHKA) is positively correlated with the malignant grade of glioma.
HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
doaj +1 more source
Protein kinase B/Akt at a glance [PDF]
Journal of Cell Science, 2005 Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression.
Brian A. Hemmings +3 more
openaire +2 more sources