Results 91 to 100 of about 2,888,198 (397)
Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B″ (δ) regulatory subunit in vitro and identification of the phosphorylation sites [PDF]
, 1998 Human erythrocyte protein phosphatase 2A, which comprises a 34-kDa catalytic C subunit, a 63-kDa regulatory A subunit and a 74-kDa regulatory B″ (δ) subunit, was phosphorylated at serine residues of B″ in vitro by cAMP-dependent protein kinase (A-kinase).
Hayashi, Hideyuki +7 more
core +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Iranian Journal of Diabetes and Obesity, 2021 Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance.
Reza Didehdar +4 more
doaj
The Occurrence of Valvular Atrial Fibrillation: Involvement of NGF/TrKA Signaling Pathway
Journal of Investigative Surgery, 2021 Objective Nerve growth factor (NGF) and tropomyosin kinase receptors A (TrKA) exert a crucial effect on the regulation of autonomic nervous system which contributes to the progress of atrial fibrillation (AF).
Qianli Wang +10 more
doaj +1 more source
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib.
Journal of the National Cancer Institute, 2005 BACKGROUND The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib (also known as Tarceva or OSI-774) has shown promising response rates in malignant gliomas.
D. Haas-Kogan +11 more
semanticscholar +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Roles of protein kinase B Akt in lung cancer [PDF]
Frontiers in Bioscience, 2010 Lung cancer is the leading cause of cancer-related death worldwide and has frequently been associated with over-activated protein kinase B (PKB)/Akt. Akt is a serine/threonine protein kinase that plays an important role in cell growth, proliferation, and survival.
Cheng-Xiong Xu +4 more
openaire +3 more sources
Cancer Research, 2005 The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and a central modulator of cell proliferation in malignant gliomas.
H. Takeuchi +6 more
semanticscholar +1 more source
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. [PDF]
, 2011 Clonal deletion of autoreactive B cells is crucial for the prevention of autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterize a previously unrecognized Ca(2+)-driven pathway for activation of the
Depeille, Philippe +7 more
core
Open Chemistry, 2019 This study aimed to reveal potential roles of the phosphatidylinositol 3 kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway in apoptosis and autophagy of astrocytes induced by methamphetamine (METH).
Liu Han-Qing +8 more
doaj +1 more source