Results 121 to 130 of about 1,944,084 (333)

Endoplasmic reticulum stressed HNSCC cell-derived exosomal miR-26a-5p promotes PD-L1 expression in macrophage through PTEN/AKT signaling pathway

open access: yes口腔疾病防治
Objective To investigate the impact of exosomal miRNAs derived from endoplasmic reticulum-stressed (ERS) head and neck squamous cell carcinoma (HNSCC) cells on macrophages. Methods This study was reviewed and approved by the Ethics Committee.
JIAO Pengfei   +8 more
doaj   +1 more source

Lattice ultrasensitivity amplifies signals in E. coli without fine-tuning [PDF]

open access: yesarXiv
The E. coli chemosensory lattice, consisting of receptors, kinases, and adaptor proteins, is an important test case for biochemical signal processing. Kinase output is characterized by precise adaptation to a wide range of background ligand levels and large gain in response to small relative changes in concentration.
arxiv  

Genomic landscape and preclinical models of angiosarcoma

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton   +3 more
wiley   +1 more source

PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

open access: yesNeural Regeneration Research
It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke. As a result, the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers.
Tianlong Liu   +6 more
doaj   +1 more source

Small Protein B upregulates sensor kinase bvgS expression in Aeromonas veronii

open access: yesFrontiers in Microbiology, 2015
Earlier studies reveal that Small Protein B (SmpB), a class of well-conserved tmRNA-binding proteins, is essential for the trans-translation process, which functions as a system for translation surveillance and ribosome rescue.
Zhu eLiu   +5 more
doaj   +1 more source

Latent periodicity of serine-threonine and tyrosine protein kinases and another protein families [PDF]

open access: yesMolekularnuya Biologiya (Russian), vol.39, N3, 2005, 2004
We identified latent periodicity in catalytic domains of approximately 85% of serine/threonine and tyrosine protein kinases. Similar results were obtained for other 22 protein domains. We also designed the method of noise decomposition, which is aimed to distinguish between different periodicity types of the same period length. The method is to be used
arxiv  

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis [PDF]

open access: yes, 1997
Various biological responses stimulated by insulin have been thought to be regulated by phosphatidylinosi-tol 3-kinase, including glucose transport, glycogen syn-thesis, and protein synthesis.
Akanuma, Y.   +10 more
core   +1 more source

B-50 Protein Kinase and Kinase C in Rat Brain [PDF]

open access: green, 1982
Vincent J. Aloyo, H. Zwiers, W.H. Gispen
openalex   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

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