Results 141 to 150 of about 1,202,909 (308)

Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells [PDF]

, 2002
Shane Donovan, Wendy L. See, Jeannette M. Bonifas, David Stokoe, Kevin Shannon   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Protein kinase B (PKB; Akt) [PDF]

Science-Business eXchange, 2009
openaire   +2 more sources

Activation of platelet protein kinase C by ultraviolet light B mediates platelet transfusion–related acute lung injury in a two‐event animal model [PDF]

, 2012
Li Zhi, Xuan Chi, Monique P. Gelderman, Jaroslav G. Vostal   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Intermittent pH changes suggest acceleration of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/ protein kinase B (AKT) pathways.

Ryota Nishida (22258400), Tomoaki Fukui (4777479), Kenichi Sawauchi (22258403), Yohei Kumabe (4777482), Hyuma Kondo (22258406), Yuya Yamamoto (667024), Kyohei Takase (22258409), Ryo Yoshikawa (5075996), Takahiro Niikura (344625), Ryosuke Kuroda (735024), Keisuke Oe (344623)   +10 more
openalex   +1 more source

Pmorf0222 , a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2

, 2022
Tenglin Xu, Yating Zheng, Benjin Liu, Mingxing Kou, Qian Jiang, Jiasen Liu, Hongtao Kang, Mingfa Yang, Dongchun Guo, Liandong Qu   +9 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Effects of Conocarpus lancifolius and crocin on superoxide dismutase and protein kinase B genes and protein expressions in diabetic rats. [PDF]

PLoS One
Lotfy M, Khalaf A, AlBarghouthy F, Alhashmi A, Adam H, Almesmari A, Kundu B, Ksiksi T.   +7 more
europepmc   +1 more source

A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. [PDF]

, 1997
Maureen R. Deehan, Margaret M. Harnett, William Harnett   +2 more
openalex   +1 more source