Results 151 to 160 of about 1,202,909 (308)

Abstract 2678: Role of protein kinase B isoforms in the unfolded protein response

, 2023
Miguel Palma, Samantha Perez, Deepali Bhandari   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

[Retracted] Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway. [PDF]

Exp Ther Med
Yan B, Wubuli A, Liu Y, Wang X.
europepmc   +1 more source

The role of Syk-family protein tyrosine kinases in B cell development.

, 2006
Farnaz Fallah‐Arani
openalex   +1 more source

Assaying AKT/Protein Kinase B Activity

, 2003
Kyle L, Hoehn, Scott A, Summers
openaire   +2 more sources

Emerging role of FKBP51 in AKT kinase/protein kinase B signaling [PDF]

Cell Cycle, 2010
Huadong, Pei, Zhenkun, Lou, Liewei, Wang
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression. [PDF]

World J Oncol
Shan H, Wang Y, Hu S, Wang Y, Qin R, Zhang N, Tian G, Qiu Z.   +7 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Phosphofructokinase B-Type Carbohydrate Kinase Family Protein, NARA5, for Massive Expressions of Plastid-Encoded Photosynthetic Genes in Arabidopsis  

, 2009
Taro Ogawa, Kenji Nishimura, Takehiko Aoki, Hisabumi Takase, Ken‐ichi Tomizawa, Hiroki Ashida, Akiho Yokota   +6 more
openalex   +1 more source