Results 271 to 280 of about 1,202,909 (308)
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Protein Kinase Activity in Hepatitis B Virus
Journal of Virology, 1980Protein kinase activity was found in hepatitis B virions (Dane particles) purified from the plasma of hepatitis B virus-infected patients, in virion cores, and in hepatitis B core antigen particles purified from hepatitis B virus-infected hepatic tissue and was not found in purified hepatitis B surface antigen particle preparations free of Dane ...
C, Albin, W S, Robinson
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Analysis of Protein Kinase B/Akt
2002Protein kinase B (PKB or Akt) was initially identified as a serine/threonine kinase with homology to protein kinases A and C, and as an oncoprotein. Three isoforms of PKB have subsequently been identified: PKBα, PKBβ, and PKBγ, which are 80% identical in amino acid sequence, and all contain an N-terminal pleckstrin homology (PH) domain and a C-terminal
Hill, Michelle M., Hemmings, Brian A.
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Physiological functions of protein kinase B/Akt
Biochemical Society Transactions, 2004The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and ...
Z-Z, Yang +5 more
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Protein Kinase C and Melanocyte Transformation
Pigment Cell Research, 1988Melanoma cells which have been isolated from metastatic melanoma tissue are able to survive and proliferate in serum supplemented media. In contrast, normal human melanocytes require the presence of growth stimulators if they are to survive in culture.
MARY BIRCH, F.L. MEYSKENS, MURRAY KORC
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Protein kinase B in the diabetic heart
Molecular and Cellular Biochemistry, 2003This paper summarizes data from different studies all aimed at elucidating regulation of protein kinase B in the diabetic heart. Two rat models of type 2 diabetes mellitus ((i) elicited via neonatal streptozotocin injection (Stz) and (ii) Zucker fa/fa rats), were used as well as different experimental models viz isolated, Langendorff perfused hearts as
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Protein kinase B: signalling roles and therapeutic targeting
Cellular and Molecular Life Sciences, 2007The serine/threonine kinase, protein kinase B (PKB, also known as Akt), is activated by a wide array of growth factors and insulin. PKB is a central player in the regulation of metabolism, apoptosis, transcription and the cell-cycle. PKB exists as three isoforms (alpha, beta and gamma) that may have unique as well as common functions within the cell ...
E M, Sale, G J, Sale
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Role of Akt/protein kinase B in metabolism
Trends in Endocrinology & Metabolism, 2002Since its discovery more than a decade ago, the Ser/Thr kinase Akt/PKB (protein kinase B) has been recognized as being remarkably well conserved across a broad range of species and involved in a diverse array of cellular processes. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in ...
Eileen L, Whiteman +2 more
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Virtual Docking Approaches to Protein Kinase B Inhibition
Journal of Medicinal Chemistry, 2005We examined some in silico approaches to identify Akt (protein kinase B) inhibitors. Experimental validation of selected compounds was achieved using a fluorescence-based enzymatic assay and a substrate phosphorylation assay involving the protein GSK-3.
FORINO, MARTINO +4 more
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly