Results 21 to 30 of about 1,202,909 (308)

A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei

mBio, 2021
In eukaryotic cells, kinetochores are large protein complexes that link chromosomes to dynamic microtubule tips, ensuring proper segregation and genomic stability during cell division.
Manuel Saldivia, Adam J. M. Wollman, Juliana B. T. Carnielli, Nathaniel G. Jones, Mark C. Leake, Christopher Bower-Lepts, Srinivasa P. S. Rao, Jeremy C. Mottram   +7 more
doaj   +1 more source

Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells

Tumor Biology, 2017
In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used.
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee   +6 more
doaj   +1 more source

Protein kinase B from Giardia intestinalis

Biochemical and Biophysical Research Communications, 2005
A novel serine/threonine protein kinase from Giardia intestinalis (GiPKB) was isolated by a combination of PCR techniques. Analysis of the GiPKB sequence indicated that the encoded protein appears to be a member of a novel subgroup of serine/threonine protein kinases known as protein kinase B. Reverse transcription PCR and Northern hybridization showed
Kyu-Tae, Kim, Myth T S, Mok, Michael R, Edwards   +2 more
openaire   +3 more sources

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system

Haematologica, 2017
Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Nele M. Belau, Martin Zimmermann, Tim Wirbelauer, Steffi Spielberg, Michaela Vossen-Gajcy, Gunnar Cario, Martin Schrappe, Denis M. Schewe   +10 more
doaj   +1 more source

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?

Frontiers in Endocrinology, 2012
The phosphoinositide 3-kinase and AKT (Protein Kinase B, PKB) signalling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth and proliferation throughout the body.
Imelda Mary McGonnell, Agamemnon Emil Grigoriadis, Eric W-F. Lam, Joanne S Price, Andrew eSunters   +4 more
doaj   +1 more source

The bright and the dark sides of L-carnitine supplementation: a systematic review

Journal of the International Society of Sports Nutrition, 2020
Background L-carnitine (LC) is used as a supplement by recreationally-active, competitive and highly trained athletes. This systematic review aims to evaluate the effect of prolonged LC supplementation on metabolism and metabolic modifications. Methods A
Angelika K. Sawicka, Gianluca Renzi, Robert A. Olek   +2 more
doaj   +1 more source

Phosphorylation of B‐50 Protein by Calcium‐Activated, Phospholipid‐Dependent Protein Kinase and B‐50 Protein Kinase

Journal of Neurochemistry, 1983
Abstract: B‐50 is a brain‐specific phosphoprotein, the phosphorylation state of which may play a role in the regulation of (poly)phosphoinositide metabolism. Several kinases were tested for their ability to phosphorylate purified B‐50 protein. Only calcium‐activated, phospholipid‐dependent protein kinase (kinase C) and B‐50 protein kinase were able to
Gispen, W.H., Aloyo, V.J., Zwiers, H.
openaire   +3 more sources

Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity [PDF]

Journal of Biological Chemistry, 1999
Protein kinase B (PKB), also known as Akt or RAC-PK, is a serine/threonine kinase that can be activated by growth factors via phosphatidylinositol 3-kinase. In this article we show that PKCzeta but not PKCalpha and PKCdelta can co-immunoprecipitate PKB from CHO cell lysates.
R P, Doornbos, M, Theelen, P C, van der Hoeven, W J, van Blitterswijk, A J, Verkleij, P M, van Bergen en Henegouwen   +5 more
openaire   +2 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice

Einstein (São Paulo)
Objective : To investigate the effects of different intensities of acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice.
Rodolfo Marinho, Leandro Pereira de Moura, Bárbara de Almeida Rodrigues, Luciana Santos Souza Pauli, Adelino Sanchez Ramos da Silva, Eloize Cristina Chiarreotto Ropelle, Claudio Teodoro de Souza, Dennys Esper Corrêa Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli   +9 more
doaj   +1 more source