Results 21 to 30 of about 2,888,198 (397)

Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]

, 2009
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura, Goya, Luis, Granado-Serrano, Ana Belen, Haegeman, Guy, Martin, Maria Anegeles, Ramos, Sonia   +5 more
core   +4 more sources

Protein kinase A-dependent phosphorylation of B/K protein [PDF]

Experimental & Molecular Medicine, 2006
We have previously isolated a novel protein "B/K" that contains two C2-like domains. Here, we report the isolation and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with rat B/K in the sequences of nucleotide and amino ...
Jeong-Hwa Lee, Seong-Whan Jeong, Oh-Joo Kwon, Sung Min Cho, Sung-Ho Choi, Yoon Seong Jang, Hemin Chin, Ho Shik Kim, In Kyung Kim, Grace J Kim   +9 more
openaire   +3 more sources

Interaction between Yeast Cdc6 Protein and B-Type Cyclin/Cdc28 Kinases [PDF]

, 1996
During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.
Campbell, Judith L., Elsasser, Suzanne, Jong, Ambrose, Lou, Feng, Wang, Bin   +4 more
core   +1 more source

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase [PDF]

Molecular and Cellular Biology, 1999
Activation of protein kinase B (PKB) by growth factors and hormones has been demonstrated to proceed via phosphatidylinositol 3-kinase (PI3-kinase). In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway. Although this activation required phosphorylation of PKB,
Chantal Filloux, Emmanuel Van Obberghen, Brian A. Hemmings, Carol L. Sable, Nathalie Filippa   +4 more
openaire   +3 more sources

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

Proceedings of the National Academy of Sciences of the United States of America, 1998
Integrin-linked kinase (ILK) is an ankyrin-repeat containing serine-threonine protein kinase capable of interacting with the cytoplasmic domains of integrin beta1, beta2, and beta3 subunits.
M. Delcommenne, C. Tan, V. Gray, Laurent Rue, J. Woodgett, S. Dedhar   +5 more
semanticscholar   +1 more source

Distinct signalling pathways mediate insulin and phorbol ester- stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells [PDF]

, 2000
Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and ...
Alessi, Alessi, Alessi, Beretta, Brostrom, Brunn, Burgering, Burnett, Cheatham, Chung, Cross, Dudley, Dufner, Favata, Flynn, Fukunaga, Gingras, Gingras, Haghighat, Hara, Haystead, Huang, Jefferies, Kitamura, Kleijn, Kohn, Kohn, Lamphear, Lin, Lin, Manzella, Marcotrigiano, Mendez, Monfar, Morley, Morley, Morley, Morris, Mukhopadhyay, Nave, Nissley, Pause, Petritsch, Polakiewicz, Price, Proud, Ptushkina, Pyronnet, Pyronnet, Rao, Rasmussen, Rau, Schonwasser, Scott, Scott, Sonenberg, Stokoe, Terada, Ueki, von Manteuffel, Vries, Wang, Waskiewicz, Waskiewicz   +63 more
core   +1 more source

Effects of Metformin on Cognitive Dysfunction and PI3K/Akt Pathway in Alzheimer's Disease Rats

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveTo investigate the effects of metformin (Met) on the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway and cognitive dysfunction in Alzheimer's disease (AD) rats.MethodsFifty Sprague Dawley rats were selected and divided into ...
WANG Baiqiao, LIN Xiaoru, HAN Min, LIU Yu, TANG Chaoling   +4 more
doaj   +1 more source

Regulated Association of Protein Kinase B/Akt with Breast Tumor Kinase [PDF]

Journal of Biological Chemistry, 2005
Increased protein-tyrosine kinase activity is a prognostic indicator of decreased disease-free survival in patients with advanced breast tumors. Breast tumor kinase (Brk) is a soluble protein-tyrosine kinase overexpressed in the majority of breast cancers and also in normal skin and gut epithelium, but not in normal breast epithelial cells.
Abby L. Olsen, Emily J. Faivre, Carol A. Lange, Daniel Fitzsimmons, Julie H. Ostrander, Ping Zhang   +5 more
openaire   +3 more sources

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little
W. Biggs, J. Meisenhelder, T. Hunter, W. Cavenee, K. Arden   +4 more
semanticscholar   +1 more source

Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor [PDF]

, 1996
The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system.
Alan J. Rosenstein, Boyle, Carlin, Cho, Dudek, Dudek, Goldenring, Grieco, Hollmann, Ishii, Kelly, Kennedy, Kennedy, Kennedy, Kindler, Kohler, Kornau, Kyung-Tai Min, Laemmli, Lieberman, Lynch, Malenka, Mary B. Kennedy, Mayer, Mayer, Mayford, McGlade-McCulloh, Melinda J. Kiely, Miller, Miller, Molloy, Monyer, Moon, Morris, Nakanishi, Nowak, Patton, Pearson, Peterson, Pettit, Podell, Ramakrishnapillai V. Omkumar, Raman, Seeburg, Silva, Smith, Squire, Stevens, Tingley, Wang, Wang, Watterson   +51 more
core   +1 more source