Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]
, 2015 BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G +4 more
core +1 more source
A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis [PDF]
, 2020 Diabetic cardiomyopathy is a progressive disease in diabetic patients, and myocardial insulin resistance contributes to its pathogenesis through incompletely-defined mechanisms.
AP Quick +38 more
core +2 more sources
International Journal for Parasitology: Drugs and Drug Resistance, 2014 Protein kinases (PKs) are one of the largest protein families in most eukaryotic organisms. These enzymes are involved in the control of cell proliferation, differentiation and metabolism and a large number of the anticancer drugs currently used are ...
Marion Morel +5 more
doaj +1 more source
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]
, 2014 The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen +53 more
core +4 more sources
Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]
, 2009 Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis +6 more
core +1 more source
Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [PDF]
, 2017 Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown.
Brennan, Cameron W. +41 more
core +2 more sources
Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications
Frontiers in Endocrinology, 2019 Accumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and ...
Zhen-Ye Zhang +8 more
doaj +1 more source
Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]
F1000Research, 2022 The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy +5 more
doaj +1 more source
Protein kinase B/Akt at a glance [PDF]
Journal of Cell Science, 2005 Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression.
Elisabeth, Fayard +3 more
openaire +2 more sources
Role of Translocation in the Activation and Function of Protein Kinase B*
Journal of Biological Chemistry, 1997 We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N terminus of protein kinase B to alter its ...
M. Andjelkovic +9 more
semanticscholar +1 more source