Results 31 to 40 of about 1,202,909 (308)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. [PDF]
PLoS Biology, 2014 The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent, characterized by drug tolerance and little or no bacterial replication.
Corrie Ortega +7 more
doaj +1 more source
Protein kinase A-dependent phosphorylation of B/K protein [PDF]
Experimental & Molecular Medicine, 2006 We have previously isolated a novel protein "B/K" that contains two C2-like domains. Here, we report the isolation and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with rat B/K in the sequences of nucleotide and amino ...
Hemin, Chin +9 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground This study investigated whether gCTRP9 (globular C1q/tumor necrosis factor–related protein‐9) could restore high‐glucose (HG)‐suppressed endothelial progenitor cell (EPC) functions by activating the endothelial nitric oxide synthase (eNOS ...
Qingsong Hu +9 more
doaj +1 more source
Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress
Shuguang Yan +5 more
doaj +1 more source
Regulated Association of Protein Kinase B/Akt with Breast Tumor Kinase [PDF]
Journal of Biological Chemistry, 2005 Increased protein-tyrosine kinase activity is a prognostic indicator of decreased disease-free survival in patients with advanced breast tumors. Breast tumor kinase (Brk) is a soluble protein-tyrosine kinase overexpressed in the majority of breast cancers and also in normal skin and gut epithelium, but not in normal breast epithelial cells.
Ping, Zhang +5 more
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
STRUCTURE, ACTIVATION AND BIOLOGICAL EFFECTS OF AKT OR PROTEIN KINASE B [PDF]
Romanian Journal of Medical Practice, 2019 AKT or protein kinase B is a serine / threonine kinase that plays a crucial role in cell proliferation, survival, growth, and glucose metabolism. So far, there have been discovered 3 isoforms of AKT, the most widespread in the tissues is AKT1.
Daniela Miricescu +8 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source