Results 41 to 50 of about 3,162,793 (373)
A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
Frontiers in Endocrinology, 2012 The phosphoinositide 3-kinase and AKT (Protein Kinase B, PKB) signalling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth and proliferation throughout the body.
Imelda Mary McGonnell +4 more
doaj +1 more source
Journal of Neurochemistry, 1983 Abstract: B‐50 is a brain‐specific phosphoprotein, the phosphorylation state of which may play a role in the regulation of (poly)phosphoinositide metabolism. Several kinases were tested for their ability to phosphorylate purified B‐50 protein. Only calcium‐activated, phospholipid‐dependent protein kinase (kinase C) and B‐50 protein kinase were able to
Gispen, W.H., Aloyo, V.J., Zwiers, H.
openaire +3 more sources
The bright and the dark sides of L-carnitine supplementation: a systematic review
Journal of the International Society of Sports Nutrition, 2020 Background L-carnitine (LC) is used as a supplement by recreationally-active, competitive and highly trained athletes. This systematic review aims to evaluate the effect of prolonged LC supplementation on metabolism and metabolic modifications. Methods A
Angelika K. Sawicka +2 more
doaj +1 more source
Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity [PDF]
Journal of Biological Chemistry, 1999 Protein kinase B (PKB), also known as Akt or RAC-PK, is a serine/threonine kinase that can be activated by growth factors via phosphatidylinositol 3-kinase. In this article we show that PKCzeta but not PKCalpha and PKCdelta can co-immunoprecipitate PKB from CHO cell lysates.
R P, Doornbos +5 more
openaire +2 more sources
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
core +1 more source
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*
Journal of Biological Chemistry, 1999 Protein kinase B lies “downstream” of phosphatidylinositide (PtdIns) 3-kinase and is thought to mediate many of the intracellular actions of insulin and other growth factors.
G. Rena +4 more
semanticscholar +1 more source
Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
Einstein (São Paulo)Objective : To investigate the effects of different intensities of acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice.
Rodolfo Marinho +9 more
doaj +1 more source
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes*
Journal of Biological Chemistry, 2005 The insulin-signaling pathway leading to the activation of Akt/protein kinase B has been well characterized except for a single step, the phosphorylation of Akt at Ser-473.
R. Hresko, M. Mueckler
semanticscholar +1 more source
Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]
, 2013 Background Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and ...
Bognár, Eszter +7 more
core +2 more sources