Results 41 to 50 of about 1,944,084 (333)

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105 [PDF]

, 1998
The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man.
Alexander Tarakhovsky, Appleby, Baixeras, Burkhardt, Cambier, Cash, Chan, Chan, Choi, Clifford A. Lowell, DeFranco, Ferrero, Fugier-Vivier, Gemma Texido, I-hsin Su, Ingrid Mecklenbräuker, Kensuke Miyake, Klaus, Klaus Rajewsky, Krieg, Law, Leitges, Li, Lowell, Lund, Marais, Marshall, Medzhitov, Medzhitov, Medzhitov, Michael Leitges, Miura, Miyake, Miyake, Nishizuka, O'Rourke, Rawlings, Richards, Rita Carsetti, Rott, Schreiber, Su, Tooze, Treisman, van Noesel, Vivien W.F. Chan, Wahl, Weiss, Wicker, Wright, Yamanashi, Yamashita, Yao   +52 more
core   +4 more sources

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?

Frontiers in Endocrinology, 2012
The phosphoinositide 3-kinase and AKT (Protein Kinase B, PKB) signalling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth and proliferation throughout the body.
Imelda Mary McGonnell, Agamemnon Emil Grigoriadis, Eric W-F. Lam, Joanne S Price, Andrew eSunters   +4 more
doaj   +1 more source

Using the structural kinome to systematize kinase drug discovery [PDF]

arXiv, 2021
Kinase-targeted drug design is challenging. It requires designing inhibitors that can bind to specific kinases when all kinase catalytic domains share a common folding scaffold that binds ATP. Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
arxiv  

Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B″ (δ) regulatory subunit in vitro and identification of the phosphorylation sites [PDF]

, 1998
Human erythrocyte protein phosphatase 2A, which comprises a 34-kDa catalytic C subunit, a 63-kDa regulatory A subunit and a 74-kDa regulatory B″ (δ) subunit, was phosphorylated at serine residues of B″ in vitro by cAMP-dependent protein kinase (A-kinase).
Hayashi, Hideyuki, Inoue, Rintaro, Kagamiyama, Hiroyuki, Nishito, Yasumasa, Shimizu, Masahiro, Takeda, Masao, Tanabe, Osamu, Usui, Hirofumi   +7 more
core   +1 more source

Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. [PDF]

PLoS Biology, 2014
The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent, characterized by drug tolerance and little or no bacterial replication.
Corrie Ortega, Reiling Liao, Lindsey N Anderson, Tige Rustad, Anja R Ollodart, Aaron T Wright, David R Sherman, Christoph Grundner   +7 more
doaj   +1 more source

Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies [PDF]

arXiv, 2020
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the ...
arxiv  

A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]

arXiv, 2022
The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv  

GAPDOCK: A genetic algorithm approach to protein docking in CAPRI round 1 [PDF]

, 2003
As part of the first Critical Assessment of PRotein Interactions, round 1, we predict the structure of two protein-protein complexes, by using a genetic algorithm, GAPDOCK, in combination with surface complementarity, buried surface area, biochemical ...
Bailey, Connolly, Connolly, Dixon, Elsom, Fieulaine, Fieulaine, Gardiner, Grindley, Kraulis, Lawrence, Mathieu, Merritt, Russell, Smith, Strynadka, Tari, Vakser   +17 more
core   +1 more source

Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation

FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.
Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese, Laura A. Hansen, Sándor Lovas   +2 more
wiley   +1 more source

Cloning of SsAkt in Sebastes schlegelii and Its Expression Pattern after Bacterial Stimulation

Progress in Fishery Sciences
Sebastes schlegelii is a cold temperate ovoviviparous fish found near the seabed layer and is widely distributed in the Yellow Sea and Bohai Sea of China, as well as in the coasts of South Korea and Japan.
Zhaolong LI, Tengteng WANG, Huizong HAN, Yuzhen CHEN, Fei WANG, Mingliang ZHANG, Shuo SUN, Weijun XIE, Haibin JIANG   +8 more
doaj   +1 more source