Results 51 to 60 of about 2,888,198 (397)
Dual Regulation of Platelet Protein Kinase B
Journal of Biological Chemistry, 2000 Protein kinase B (PKB) is a serine/threonine kinase that is activated by growth hormones and implicated in prevention of apoptosis, glycogen metabolism, and glucose uptake. A key enzyme in PKB activation is phosphatidylinositide 3-kinase (PI-3K), which triggers the dual phosphorylation of PKB by phosphatidylinositol-dependent kinases (PDKs).
Kurt L. Eybrechts +2 more
openaire +3 more sources
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin. [PDF]
Proceedings of the National Academy of Sciences, 1991 Solid-phase binding assays with protein species purified from cultured rat glioma C6 cells and Ehrlich ascites revealed that plectin bound specifically to lamin B but not to lamins A and C. Lamin B interaction was significantly decreased upon in vitro phosphorylation of either lamin B or plectin with protein kinase A or C.
Gerhard Wiche +2 more
openaire +4 more sources
GAPDOCK: A genetic algorithm approach to protein docking in CAPRI round 1 [PDF]
, 2003 As part of the first Critical Assessment of PRotein Interactions, round 1, we predict the structure of two protein-protein complexes, by using a genetic algorithm, GAPDOCK, in combination with surface complementarity, buried surface area, biochemical ...
Bailey +17 more
core +1 more source
Haematologica, 2017 Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq +10 more
doaj +1 more source
A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
Frontiers in Endocrinology, 2012 The phosphoinositide 3-kinase and AKT (Protein Kinase B, PKB) signalling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth and proliferation throughout the body.
Imelda Mary McGonnell +4 more
doaj +1 more source
Differential regulation of NPR-B/GC-B by protein kinase C and calcium [PDF]
BMC Pharmacology, 2005 C-type natriuretic peptide (CNP) activation of the guanylyl cyclase-linked natriuretic peptide receptor-B (NPR-B) stimulates vasorelaxation and bone growth. Hormones and phorbol esters (PMA) inhibit NPR-B in calcium and protein kinase c-dependent manners, respectively.
Dmitri Smirnov +2 more
openaire +4 more sources
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*
Journal of Biological Chemistry, 1999 Protein kinase B lies “downstream” of phosphatidylinositide (PtdIns) 3-kinase and is thought to mediate many of the intracellular actions of insulin and other growth factors.
G. Rena +4 more
semanticscholar +1 more source
Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]
, 2009 Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis +6 more
core +1 more source
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes*
Journal of Biological Chemistry, 2005 The insulin-signaling pathway leading to the activation of Akt/protein kinase B has been well characterized except for a single step, the phosphorylation of Akt at Ser-473.
R. Hresko, M. Mueckler
semanticscholar +1 more source
SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]
, 2009 CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M. +3 more
core +2 more sources