Results 51 to 60 of about 3,162,793 (373)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Protein kinase A-dependent phosphorylation of B/K protein [PDF]

Experimental & Molecular Medicine, 2006
We have previously isolated a novel protein "B/K" that contains two C2-like domains. Here, we report the isolation and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with rat B/K in the sequences of nucleotide and amino ...
Hemin, Chin, Sung Ho, Choi, Yoon Seong, Jang, Sung Min, Cho, Ho Shik, Kim, Jeong Hwa, Lee, Seong Whan, Jeong, In Kyung, Kim, Grace J, Kim, Oh Joo, Kwon   +9 more
openaire   +2 more sources

Endocrine therapy: defining the path of least resistance [PDF]

, 2014
One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling.
Musgrove, Elizabeth A., Stone, Andrew
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

C1q/Tumor Necrosis Factor–Related Protein‐9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose‐Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study investigated whether gCTRP9 (globular C1q/tumor necrosis factor–related protein‐9) could restore high‐glucose (HG)‐suppressed endothelial progenitor cell (EPC) functions by activating the endothelial nitric oxide synthase (eNOS ...
Qingsong Hu, Wan Qu, Tao Zhang, Jianyi Feng, Xiaobian Dong, Ruqiong Nie, Junyu Chen, Xiaoqing Wang, Changnong Peng, Xiao Ke   +9 more
doaj   +1 more source

Regulated Association of Protein Kinase B/Akt with Breast Tumor Kinase [PDF]

Journal of Biological Chemistry, 2005
Increased protein-tyrosine kinase activity is a prognostic indicator of decreased disease-free survival in patients with advanced breast tumors. Breast tumor kinase (Brk) is a soluble protein-tyrosine kinase overexpressed in the majority of breast cancers and also in normal skin and gut epithelium, but not in normal breast epithelial cells.
Ping, Zhang, Julie Hanson, Ostrander, Emily J, Faivre, Abby, Olsen, Daniel, Fitzsimmons, Carol A, Lange   +5 more
openaire   +2 more sources

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response. [PDF]

, 2015
The Akt protein kinase, also known as protein kinase B, plays key roles in insulin receptor signalling and regulates cell growth, survival and metabolism. Recently, we described a mechanism to enhance Akt phosphorylation that restricts access of cellular
Armen, Roger S., Blumhof, Brian, Chan, Tung O., Keny, Nikhil, Li, Xue, Pascal, John M., Penn, Raymond B., Penny, Morgan, Rodeck, Ulrich, Tiegs, Brian C., Yan, Linda, Zhang, Jin   +11 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. [PDF]

PLoS Biology, 2014
The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent, characterized by drug tolerance and little or no bacterial replication.
Corrie Ortega, Reiling Liao, Lindsey N Anderson, Tige Rustad, Anja R Ollodart, Aaron T Wright, David R Sherman, Christoph Grundner   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source