Results 71 to 80 of about 1,944,084 (333)
Journal of Lipid Research, 2015 Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan +3 more
doaj
Tumor Biology, 2017 The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related
Xiao-Qin He +9 more
doaj +1 more source
Critical phenomena in the temperature-pressure-crowding phase diagram of a protein [PDF]
Phys. Rev. X 9, 041035 (2019), 2019 In the cell, proteins fold and perform complex functions through global structural rearrangements. Function requires a protein to be at the brink of stability to be susceptible to small environmental fluctuations, yet stable enough to maintain structural integrity.
arxiv +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]
, 2009 CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M. +3 more
core +2 more sources
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Putative mechanism of a multivitamin treatment against insulin resistance
AdipocyteInsulin resistance is caused by the abnormal secretion of proinflammatory cytokines in adipose tissue, which is induced by an increase in lipid accumulation in adipocytes, hepatocytes, and myocytes. The inflammatory pathway involves multiple targets such
José Antonio Palma-Jacinto +4 more
doaj +1 more source
Giant Hub Src and Syk Tyrosine Kinase Thermodynamic Profiles Recapitulate Evolution [PDF]
, 2016 Thermodynamic scaling theory, previously applied mainly to small proteins, here analyzes quantitative evolution of the titled functional network giant hub enzymes. The broad domain structure identified homologically is confirmed hydropathically using amino acid sequences only.
arxiv +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
STRUCTURE, ACTIVATION AND BIOLOGICAL EFFECTS OF AKT OR PROTEIN KINASE B [PDF]
Romanian Journal of Medical Practice, 2019 AKT or protein kinase B is a serine / threonine kinase that plays a crucial role in cell proliferation, survival, growth, and glucose metabolism. So far, there have been discovered 3 isoforms of AKT, the most widespread in the tissues is AKT1.
Daniela Miricescu +8 more
doaj +1 more source