Results 181 to 190 of about 1,243,636 (309)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Differential regulation of P2Y₁₁ receptor‐mediated signalling to phospholipase C and adenylyl cyclase by protein kinase C in HL‐60 promyelocytes [PDF]

, 2000
Byung‐Chang Suh, Tae‐Don Kim, Ihn‐Soon Lee, Kyong‐Tai Kim   +3 more
openalex   +1 more source

Unraveling the protein kinase C/NDRG1 signaling network in breast cancer. [PDF]

Cell Biosci
Saponaro C, Damato M, Stanca E, Aboulouard S, Zito FA, De Summa S, Traversa D, Schirosi L, Bravaccini S, Pirini F, Fonzi E, Tebaldi M, Puccetti M, Gaballo A, Pantalone L, Ronci M, Magnani L, Sergi D, Tinelli A, Tacconi S, Siculella L, Giudetti AM, Fournier I, Salzet M, Trerotola M, Vergara D.   +25 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Protein Kinase C (PKC)α and PKCθ Are the Major PKC Isotypes Involved in TCR Down-Regulation [PDF]

, 2006
Marina Rode von Essen, Martin Weiss Nielsen, Charlotte M. Bonefeld, Lasse Boding, Jeppe Madura Larsen, Michael Leitges, Gottfried Baier, Niels Ødum, Carsten Geisler   +8 more
openalex   +1 more source

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage-Dependent Calcium Channels and Protein Kinase C. [PDF]

J Appl Toxicol
Zaniboni BA, Oliveira VS, Leite GAA, Grinevicius VMAS, Pedrosa RC, Silva FRMB.   +5 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Tumor Necrosis Factor-α Autoregulates Interleukin-6 Synthesis via Activation of Protein Kinase C

, 1997
Osamu Kozawa, Atsushi Suzuki, Takehiro Kaida, Haruhiko Tokuda, Toshihiko Uematsu   +4 more
openalex   +1 more source

Protein Kinase C Epsilon Overexpression Protects the Heart Against Doxorubicin-Induced Cardiotoxicity Via Activating SIRT1. [PDF]

Cardiovasc Toxicol
Liu D, Wang C, Chen Y, Huang X, Wen Y, Duan S, Cai Y, Li X, He J, Han K, Li T, Li Y, Xia Z.   +12 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source