Results 261 to 270 of about 1,243,636 (309)

Protein kinase C inhibitors

Current Oncology Reports, 2002
Protein kinase C (PKC) is a family of serine-threonine protein kinases that are involved in signal transduction pathways that regulate growth factor response, proliferation, and apoptosis. Its central role in these processes, which are closely involved in tumor initiation, progression, and response to antitumor agents, makes it an attractive ...
Helen C, Swannie, Stanley B, Kaye
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AGC protein kinase phosphorylation and protein kinase C

Biochemical Society Transactions, 2001
Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events?
Parker, P J, Parkinson, S J
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The protein kinase C and protein kinase C related gene families

Current Opinion in Structural Biology, 1995
Protein kinase C is an important target enzyme for lipid second messengers. Recent developments have focused on the tertiary structure analysis of domains present in protein kinase C and in combination with functional approaches such as mutagenesis and domain expression have generated a detailed understanding of the modular mechanism by which lipids ...
L V, Dekker, R H, Palmer, P J, Parker
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The protein kinase C family

European Journal of Biochemistry, 1992
Protein kinase C represents a structurally homologous group of proteins similar in size, structure and mechanism of activation. They can modulate the biological function of proteins in a rapid and reversible manner. Protein kinase C participates in one of the major signal transduction systems triggered by the external stimulation of cells by various ...
A, Azzi, D, Boscoboinik, C, Hensey
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Protein kinase C and beyond

Nature Immunology, 2004
Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells.
Spitaler, Martin, Cantrell, Doreen A
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Ethanol and Protein Kinase C

Alcoholism: Clinical & Experimental Research, 1999
Protein kinase C (PKC) is involved in the control of many key signaling pathways in cells. Investigations over the past decade have shown that many effects of ethanol on cell function are closely interconnected with PKC. Three distinct areas of investigation have emerged; they are reviewed in this article.
C D, Stubbs, S J, Slater
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Protein kinase C binding partners

BioEssays, 2000
Members of the protein kinase C family respond to second messengers and are involved in controlling a broad array of cellular functions. The overlapping specificity and promiscuity of these proteins has promoted the view that specific binding proteins constrain individual family members to create the appropriate specificity of action.
Jaken, S, Parker, P J
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Smooth muscle protein kinase C

Canadian Journal of Physiology and Pharmacology, 1994
Protein kinase C (PKC) was first implicated in the regulation of smooth muscle contraction with the observation that phorbol esters induce slowly developing, sustained contractions. In some vascular smooth muscles, e.g., ferret aorta, phorbol ester induced contractions occur without an increase in sarcoplasmic free-Ca2+ concentration ([Ca]i) or myosin
M P, Walsh, J E, Andrea, B G, Allen, O, Clément-Chomienne, E M, Collins, K G, Morgan   +5 more
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Protein kinase C in melanoma

Cancer and Metastasis Reviews, 2005
Protein kinase C (PKC) is activated by diacylglycerol generated by receptor-mediated hydrolysis of membrane phospholipids to mediate signals for cell growth and plays as a target of tumor-promoting phorbol esters in malignant transformation. PKC is a family of enzymes and their expression profiles have been examined in the normal melanocytes and ...
Masahiro, Oka, Ushio, Kikkawa
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Integrin–protein kinase C relationships

Biochemical Society Transactions, 2003
The integrins have an ability to interact with extracellular matrix proteins to confer adhesive and motile properties on cells. The means by which these activities operate and the manner in which they are integrated with cell functions is of particular relevance to many biological processes.
Ivaska, J, Kermorgant, S, Whelan, R, Parsons, M, Ng, T, Parker, P J   +5 more
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