Results 31 to 40 of about 1,861,293 (359)

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487 [PDF]

, 2016
The key metabolic regulator, AMP-activated protein kinase (AMPK) is reported to be downregulated in metabolic disorders, but the mechanisms are poorly characterised.
Anastasiya Strembitska, Berggreen, Bijland, Boyle, Chang, Coughlan, Coughlan, Dagon, Deshmukh, Duarte, Garcia-Haro, Gauthier, Geraldes, Guerra, Gwyn W. Gould, Hall, Hardie, Hardie, Hawley, Hawley, Hawley, Helen R. Heathcote, Horman, Hurley, Ian P. Salt, James A. Reihill, Javadov, Kim, Kohlhaas, Komander, Kunzah Jamal, Laderoute, Liu, Lu, López-Cotarelo, Martin, Matsuda, Matthews, Morrow, Ning, Nishino, Palmer, Park, Reihill, Reihill, Ruderman, Saberi, Salt, Sapkota, Sarah J. Mancini, Schmitz-Peiffer, Soltys, Stone, Timothy M. Palmer, Tsai, Tsuchiya, Valentine, Woods, Woods, Xu, Young   +60 more
core   +6 more sources

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. [PDF]

, 2007
Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy.
Bose, Ron, Cole, Philip A, Jura, Natalia, Kuriyan, John, Pickin, Kerry A, Zhang, Xuewu   +5 more
core   +1 more source

H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]

, 2009
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi, F. Y. Meng, FRANCHITTO, Antonio, G. Alpini, G. Carpino, GAUDIO, EUGENIO, H. Francis, J. Venter, M. White, MANCINELLI, ROMINA, ONORI, PAOLO, R. Sferra, S. Demorrow, S. Kopriva   +13 more
core   +1 more source

Protein kinase C signaling and cell cycle regulation

Frontiers in Immunology, 2013
A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about thirty years. However, despite the wealth of information on PKC-mediated control of T cell activation, understanding of ...
Adrian R Black, Jennifer D Black
doaj   +1 more source

Protein kinase C regulates human pluripotent stem cell self-renewal. [PDF]

PLoS ONE, 2013
The self-renewal of human pluripotent stem (hPS) cells including embryonic stem and induced pluripotent stem cells have been reported to be supported by various signal pathways.
Masaki Kinehara, Suguru Kawamura, Daiki Tateyama, Mika Suga, Hiroko Matsumura, Sumiyo Mimura, Noriko Hirayama, Mitsuhi Hirata, Kozue Uchio-Yamada, Arihiro Kohara, Kana Yanagihara, Miho K Furue   +11 more
doaj   +1 more source

Protein tyrosine kinase but not protein kinase C inhibition blocks receptor induced alveolar macrophage activation

Mediators of Inflammation, 1993
The selective enzyme inhibitors genistein and Ro 31-8220 were used to assess the importance of protein tyrosine kinase (PTK) and protein kinase C (PKC), respectively, in N-formyl-methionyl-leucyl-phenylalanine (FMLP) induced generation of superoxide ...
K. Pollock, M. T. Withnall
doaj   +1 more source

Role of Protein Kinase C in Eosinophil Function

Allergology International, 2006
Protein kinase C (PKC) isoforms are being elucidated as an increasingly diverse family of enzymes involved in the downstream signal transduction and cell function in various types of cells.
Takafumi Yamaguchi, Masato Suzuki, Hirokazu Kimura, Masahiko Kato   +3 more
doaj   +1 more source

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]

, 2015
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo, Fumagallo, Felipe, Gillespie, David A., Gong, Eun Yeung, Morrice, Nicholas, Piscitello, Desiree, Smits, Veronique A.J.   +6 more
core   +1 more source

Angiotensin II Directly Triggers Endothelial Exocytosis via Protein Kinase C-Dependent Protein Kinase D2 Activation

Journal of Pharmacological Sciences, 2007
Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown.
Xiaona Ge, Brad Low, Mei Liang, Jian Fu
doaj   +1 more source