Results 201 to 210 of about 2,154,176 (393)

Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation. [PDF]

Molecules, 2023
Alanazi MM, Alanazi AS.
europepmc   +1 more source

Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen-activated protein kinase-caspase-3 signaling pathway following cerebral ischemia-reperfusion injury

, 2017
Da Li, Yanqiu Ai
openalex   +2 more sources

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

Clinical and Experimental Immunology, 2014
H. C. Patterson, R. Nibbs, I. McInnes, S. Siebert   +3 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Retraction Note: Identification of protein kinase inhibitors to reprogram breast cancer cells. [PDF]

Cell Death Dis, 2022
Yuan J, Zhang F, You M, Yang Q.
europepmc   +1 more source

Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells

, 2018
Sumiyasuren Buyanravjikh, Sora Han, Sunyi Lee, Ae Lee Jeong, Hye In Ka, Ji Park, Ariundavaa Boldbaatar, Jong‐Seok Lim, Myeong‐Sok Lee, Young Yang   +9 more
openalex   +2 more sources

Data from A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth <i>In vitro</i> and <i>In vivo</i>

, 2023
Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Nobuo Ochi, Zhimin Tong, Amit Deorukhkar, Bokyung Sung, Lloyd R. Kèlland, Stephen M. F. Jamieson, Rachel Sutherland, Tony Raynham, Mark Charles, Azadeh Bagherzadeh, Caroline Foxton, Alexandra Boakes, Muddasar Farooq, Dipen M. Maru, Parmeswaran Diagaradjane, Yoichi Matsuo, James Sinnett‐Smith, Juri G. Gelovani, Sunil Krishnan, Bharat B. Aggarwal, Enrique Rozengurt, Christopher R. Ireson, Sushovan Guha   +24 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Revisiting the inhibitory potential of protein kinase inhibitors against NEK7 protein via comprehensive computational investigations. [PDF]

Sci Rep, 2023
Ejaz SA, Aziz M, Zafar Z, Akhtar N, Ogaly HA.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source