Results 221 to 230 of about 608,807 (260)

Peptide Inhibitors Targeting Protein Kinases

Current Pharmaceutical Design, 2009
Phosphorylation by protein kinases is a central theme in biological systems. Aberrant protein kinase activity has been implicated in a variety of human diseases, therefore, modulation of kinase activity represents an attractive therapeutic approach for the treatment of human illnesses.
Hagit, Eldar-Finkelman, Miriam, Eisenstein   +1 more
openaire   +2 more sources

Profiling of inhibitors of protein kinase C

Advances in Enzyme Regulation, 1988
A rapid screen assay for protein kinase C was described which allowed the detection of inhibitors and activators of the enzyme at different states of activation. Upon secondary evaluation of the active inhibitors, three classes of compounds were identified.
L P, Wennogle, H E, Wysowskyj, A Y, Jeng
openaire   +2 more sources

Ruthenium Complexes as Protein Kinase Inhibitors

Organic Letters, 2004
[reaction: see text] Replacing complex natural products with simple metal complexes could lead to a new class of metallopharmaceuticals in which the metal center plays mainly a structural role. A strategy is introduced for the creation of ruthenium complex-based protein kinase inhibitors 1 (X = CO or CH(2)), morphed out of the class of indolocarbazole ...
Lilu, Zhang, Patrick, Carroll, Eric, Meggers   +2 more
openaire   +2 more sources

Rottlerin, a Novel Protein Kinase Inhibitor

Biochemical and Biophysical Research Communications, 1994
Rottlerin, a compound from Mallotus philippinensis, is shown to inhibit protein kinases with some specificity for PKC. To some extent, the novel inhibitor is able to differentiate between PKC isoenzymes, with IC50 values for PKC delta of 3-6 microM, PKC alpha,beta,gamma of 30-42 microM and PKC epsilon,eta,zeta of 80-100 microM.
M, Gschwendt, H J, Müller, K, Kielbassa, R, Zang, W, Kittstein, G, Rincke, F, Marks   +6 more
openaire   +2 more sources

Protein kinase inhibitors and antibiotic resistance

Pharmacology & Therapeutics, 2002
While antibiotics revolutionized the treatment of infectious disease in the 20th century, bacterial resistance now threatens to render many of them ineffective. Aminoglycosides are a class of clinically important antibiotics used in the treatment of infections caused by Gram-positive and -negative organisms.
David L, Burk, Albert M, Berghuis
openaire   +2 more sources

The Protein Kinase C Inhibitor: Ruboxistaurin

2015
The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia. This family of serine/threonine-specific protein kinases comprises several different members, which differ in their structure, cofactor requirement and substrate specificity.
Heidrun L, Deissler, Gabriele E, Lang
openaire   +2 more sources

Physiological inhibitors of protein kinase C

Biochemical Pharmacology, 1996
Increasing numbers of proteins that have the capacity of interacting with protein kinase C isozymes in vitro and inhibiting their enzymatic activity in a noncompetitive manner have been purified. While these proteins can be hypothesized to be part of a tight regulatory system for protein kinase C enzymatic activity, critical examinations of the roles ...
openaire   +2 more sources

Discovery of Protein Kinase Phosphatase Inhibitors

2006
Dynamic protein phosphorylation, a major cellular regulatory system, is tightly controlled by coordinating the reversible action of protein kinases and phosphatases. Recent evidence is consistent with sophisticated mechanisms that regulate both kinases and phosphatases in the cell.
Andreas, Vogt, John S, Lazo
openaire   +2 more sources

Inhibitors of protein kinases

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
David, Shugar, Doriano, Fabbro
openaire   +2 more sources

Physiological functions of protein kinase inhibitors

2000
Protein kinases are key regulatory enzymes involved in a multitude of biochemical pathways. This chapter will describe the current research on targeting specific protein kinases with inhibitors in attempts to disrupt flux through specific pathways.
J J, Turchi, M, Ho
openaire   +2 more sources