Results 231 to 240 of about 2,078,021 (401)

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Novel 5-Oxopyrrolidine-3-carbohydrazides as Potent Protein Kinase Inhibitors: Synthesis, Anticancer Evaluation, and Molecular Modeling. [PDF]

Int J Mol Sci
Tumosienė I, Stasevych M, Zvarych V, Jonuškienė I, Kantminienė K, Petrikaitė V.   +5 more
europepmc   +1 more source

Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni. [PDF]

Front Cell Infect Microbiol, 2022
Moreira BP, Batista ICA, Tavares NC, Armstrong T, Gava SG, Torres GP, Mourão MM, Falcone FH.   +7 more
europepmc   +1 more source

Agents that Activate Cyclic AMP-Dependent Protein Kinase Inhibit Explant Culture Growth and Mitotic Activity

, 1983
Kenneth M. Halprin, J. Richard Taylor, Victor Levine, Clyde Woodyard, Kenji Adachi, Mary Comerford   +5 more
openalex   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers. [PDF]

JCO Precis Oncol
Dankner M, Rousselle E, Petrecca S, Fabi F, Nowakowski A, Lazaratos AM, Rajadurai CV, Stein AJB, Bian D, Tai P, Belaiche A, Li M, Quaiattini A, Normanno N, Arcila M, Elkrief A, Johnson DB, Ladanyi M, Rose AAN.   +18 more
europepmc   +1 more source

Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors. [PDF]

J Exp Clin Cancer Res, 2021
Yuan J, Zhang F, Hallahan D, Zhang Z, He L, Wu LG, You M, Yang Q.   +7 more
europepmc   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Searching for Old and New Small-Molecule Protein Kinase Inhibitors as Effective Treatments in Pulmonary Hypertension-A Systematic Review. [PDF]

Int J Mol Sci
Jasińska-Stroschein M, Glajzner P.
europepmc   +1 more source

A novel graph convolutional neural network for predicting interaction sites on protein kinase inhibitors in phosphorylation. [PDF]

Sci Rep, 2022
Wang F, Chen YT, Yang JM, Akutsu T.
europepmc   +1 more source