Results 241 to 250 of about 2,154,176 (393)

Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers. [PDF]

JCO Precis Oncol
Dankner M, Rousselle E, Petrecca S, Fabi F, Nowakowski A, Lazaratos AM, Rajadurai CV, Stein AJB, Bian D, Tai P, Belaiche A, Li M, Quaiattini A, Normanno N, Arcila M, Elkrief A, Johnson DB, Ladanyi M, Rose AAN.   +18 more
europepmc   +1 more source

Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni. [PDF]

Front Cell Infect Microbiol, 2022
Moreira BP, Batista ICA, Tavares NC, Armstrong T, Gava SG, Torres GP, Mourão MM, Falcone FH.   +7 more
europepmc   +1 more source

Inhibition of Acid Secretion in Gastric Parietal Cells by the Ca2+/ Calmodulin-Dependent Protein Kinase II Inhibitor KN-93.

, 1994
Naoto Mamiya, James R. Goldenring, Yasuhiro Tsunoda, Irvin M. Modlin, Kiyoshi Yasui, N Usuda, Hiroyoshi Hidaka   +6 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Updated analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Obst CS, Seifert R.
europepmc   +1 more source

Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors. [PDF]

J Exp Clin Cancer Res, 2021
Yuan J, Zhang F, Hallahan D, Zhang Z, He L, Wu LG, You M, Yang Q.   +7 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Searching for Old and New Small-Molecule Protein Kinase Inhibitors as Effective Treatments in Pulmonary Hypertension-A Systematic Review. [PDF]

Int J Mol Sci
Jasińska-Stroschein M, Glajzner P.
europepmc   +1 more source

A novel graph convolutional neural network for predicting interaction sites on protein kinase inhibitors in phosphorylation. [PDF]

Sci Rep, 2022
Wang F, Chen YT, Yang JM, Akutsu T.
europepmc   +1 more source

Differential action of a protein tyrosine kinase inhibitor, genistein, on the positive inotropic effect of endothelin‐1 and norepinephrine in canine ventricular myocardium [PDF]

, 2005
Li Chu, Jianxin Zhang, Ikuo Norota, Masao Endoh   +3 more
openalex   +1 more source