Results 91 to 100 of about 23,156,384 (284)

Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress [PDF]

Molecular and Cellular Biology, 2017
High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor κB (NF-κB) p65 species phosphorylated at serine-536, which is ...
Farabaugh, Kenneth T, Majumder, Mithu, Guan, Bo-Jhih, Jobava, Raul, Wu, Jing, Krokowski, Dawid, Gao, Xing-Huang, Schuster, Andrew, Longworth, Michelle, Chan, Edward D, Bianchi, Massimiliano, Dey, Madhusudan, Koromilas, Antonis E, Ramakrishnan, Parameswaran, Hatzoglou, Maria   +14 more
openaire   +4 more sources

The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia–reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis

Acta Pharmaceutica Sinica B
Receptor-interacting protein kinase 1 (RIPK1) plays an essential role in regulating the necroptosis and apoptosis in cerebral ischemia-reperfusion (I/R) injury.
Tengfei Liu, Gan Huang, Xin Guo, Qiuran Ji, Lu Yu, Runzhe Zong, Yiquan Li, Xiaomeng Song, Qingyi Fu, Qidi Xue, Yi Zheng, Fanshuo Zeng, Ru Sun, Lin Chen, Chengjiang Gao, Huiqing Liu   +15 more
doaj   +1 more source

Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia–reperfusion injury by inhibiting TAK1/JNK/p38 pathway

Scientific Reports, 2023
Mitogen activated protein kinase phosphatase 5 (MKP5) is a member of the MKP family and has been implicated in diverse biological and pathological conditions. However, it is unknown what role MKP5 plays in liver ischemia/reperfusion (I/R) injury.
Qiwen Yu, Sanyang Chen, Jiye Li, Hongwei Tang, Jihua Shi, Wenzhi Guo, Shuijun Zhang   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus [PDF]

Journal of Virology, 2018
ABSTRACT While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from this rule. For example, rhesus macaque CMV (RhCMV), a model for human CMV (HCMV) pathogenesis and vaccine development, can replicate in human cells, as well as in rhesus cells.
Stephanie J, Child, Sarah E, Hickson, Avraham, Bayer, Daniel, Malouli, Klaus, Früh, Adam P, Geballe   +5 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C [PDF]

, 1994
Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L., Hummel, R., Schächtele, C., Wenzel-Seifert, K., Seifert, Roland   +4 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Huang, T., Day, Jonathan P., Day, Jonathan P, Baillie, George S., Guercio, L.A., Luczak, V., Nie, T., Scott, J.D., Guercio, Leonardo A., Baillie, G.S., Abel, T., Gelman, I.H., Park, Alan J, Canton, David A., Scott, John D., Havekes, R., Nie, Ting, Gelman, Irwin H, Canton, D.A., Park, Alan J., Grimes, Quinn, Grimes, Q., Luczak, Vincent G, Havekes, Robbert, Park, A.J., Guercio, Leonardo A, Baillie, George S, Abel, Ted, Gelman, Irwin H., Luczak, Vincent, Day, J.P., Canton, David A, Huang, Ted   +32 more
core   +1 more source