Results 1 to 10 of about 10,656 (197)

Poxviruses in Bats … so What? [PDF]

Viruses, 2014
Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host.
Kate S. Baker, Pablo R. Murcia
doaj   +4 more sources

Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion [PDF]

Biomedicines, 2021
Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs), which are molecular signatures shared by different pathogens.
Huibin Yu, Ryan C. Bruneau, Greg Brennan, Stefan Rothenburg   +3 more
doaj   +4 more sources

TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository [PDF]

Proteomes
Background: Poxviruses constitute a family of large dsDNA viruses that can infect a plethora of species including humans. Historically, poxviruses have caused a health burden in multiple outbreaks.
Mansi Dutt, Anuj Kumar, Ali Toloue Ostadgavahi, David J. Kelvin, Gustavo Sganzerla Martinez   +4 more
doaj   +4 more sources

A selectable and excisable marker system for the rapid creation of recombinant poxviruses. [PDF]

PLoS ONE, 2011
Genetic manipulation of poxvirus genomes through attenuation, or insertion of therapeutic genes has led to a number of vector candidates for the treatment of a variety of human diseases.
Julia L Rintoul, Jiahu Wang, Don B Gammon, Nicholas J van Buuren, Kenneth Garson, Karen Jardine, Michele Barry, David H Evans, John C Bell   +8 more
doaj   +4 more sources

Formulation of next-generation polyvalent vaccine candidates against three important poxviruses by targeting DNA-dependent RNA polymerase using an integrated immunoinformatics and molecular modeling approach

Journal of Infection and Public Health
Background: Poxviruses comprise a group of large double-stranded DNA viruses and are known to cause diseases in humans, livestock animals, and other animal species. The Mpox virus (MPXV; formerly Monkeypox), variola virus (VARV), and volepox virus (VPXV)
Anuj Kumar, Mansi Dutt, Budheswar Dehury, Gustavo Sganzerla Martinez, Krishna Pal Singh, David J. Kelvin   +5 more
doaj   +3 more sources

Enhancing the Protective Immune Response to Administration of a LIVP-GFP Live Attenuated Vaccinia Virus to Mice

Pathogens, 2021
Following the WHO announcement of smallpox eradication, discontinuation of smallpox vaccination with vaccinia virus (VACV) was recommended. However, interest in VACV was soon renewed due to the opportunity of genetic engineering of the viral genome by ...
Sergei N. Shchelkunov, Stanislav N. Yakubitskiy, Kseniya A. Titova, Stepan A. Pyankov, Alexander A. Sergeev   +4 more
doaj   +1 more source

Why do poxviruses still matter?

Cell & Bioscience, 2021
Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public health concerns and serious endemic diseases ...
Zhilong Yang, Mark Gray, Lake Winter
doaj   +1 more source

Fludarabine, a Potential DNA-Dependent RNA Polymerase Inhibitor, as a Prospective Drug against Monkeypox Virus: A Computational Approach

Pharmaceuticals, 2022
Monkeypox is a zoonotic contagious disease that has recently re-emerged in different countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there is an urgent need to find effective drugs to stop the spread of the multi-
Hisham N. Altayb
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Comparative analysis of existing platforms for the development of vaccines against dangerous and extremely dangerous viral infections with pandemic potential

Биопрепараты: Профилактика, диагностика, лечение, 2021
The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko, T. E. Sizikova, V. N. Lebedev, S. V. Borisevich   +3 more
doaj   +1 more source

Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats

Biomolecules, 2023
Cowpox viruses (CPXVs) exhibit the broadest known host range among the Poxviridae family and have caused lethal outbreaks in various zoo animals and pets across 12 Eurasian countries, as well as an increasing number of human cases.
Ryan C. Bruneau, Loubna Tazi, Stefan Rothenburg   +2 more
doaj   +1 more source