TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository [PDF]
ProteomesBackground: Poxviruses constitute a family of large dsDNA viruses that can infect a plethora of species including humans. Historically, poxviruses have caused a health burden in multiple outbreaks.
Mansi Dutt +4 more
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Emerging interplays between poxviruses and autophagy [PDF]
Frontiers in Cellular and Infection MicrobiologyPoxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm. Their life cycle is closely associated with various membrane-related cellular processes.
Yongge Li +4 more
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Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion
Biomedicines, 2021 Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs), which are molecular signatures shared by different pathogens.
Huibin Yu +2 more
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Viruses, 2014 Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host.
Kate S Baker +2 more
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Journal of Infection and Public HealthBackground: Poxviruses comprise a group of large double-stranded DNA viruses and are known to cause diseases in humans, livestock animals, and other animal species. The Mpox virus (MPXV; formerly Monkeypox), variola virus (VARV), and volepox virus (VPXV)
Anuj Kumar +2 more
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A Selectable and Excisable Marker System for the Rapid Creation of Recombinant Poxviruses [PDF]
PLoS ONE, 2011 Genetic manipulation of poxvirus genomes through attenuation, or insertion of therapeutic genes has led to a number of vector candidates for the treatment of a variety of human diseases.
Jiahu Wang +2 more
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Rapid spread of MPXV clade Ib with high genetic relatedness among men who have sex with men, Berlin, Germany, week 50 2025 up to week 10 2026 [PDF]
EurosurveillanceFollowing the first detection of monkeypox virus (MPXV) clade Ib in Berlin, Germany, in December 2025, clade Ib rapidly predominated over clade IIb among notified mpox cases.
Janine Michel
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Poxvirus A52 protein subverts autophagy flux by blocking autophagosome-lysosome fusion to promote viral replication. [PDF]
PLoS PathogensMany poxviruses are significant zoonotic pathogens threatening public health. Autophagy, a regulated process vital for cellular homeostasis, can participate in defense against virus invasion.
Kang Niu +9 more
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Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park +6 more
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Why do poxviruses still matter?
Cell & Bioscience, 2021 Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public health concerns and serious endemic diseases ...
Zhilong Yang, Mark Gray, Lake Winter
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