Results 31 to 40 of about 9,912 (196)
Viruses, 2021 Mass vaccination has played a critical role in the global eradication of smallpox. Various vaccinia virus (VACV) strains, whose origin has not been clearly documented in most cases, have been used as live vaccines in different countries.
Sergei N. Shchelkunov +11 more
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Monkeypox: A Little-Studied Biological Threat to Russia
Вестник войск РХБ защиты, 2023 Monkeypox is a natural focal zoonosis of rodents and monkeys living in the Congo Valley (clade CB) and West Africa (clade WA). The special interest in monkeypox is due to its pandemic spread, which began in May 2022.
M. V. Supotnitskiy
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Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R
Viruses, 2022 Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman +3 more
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Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
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Enhancing the Immunogenicity of Vaccinia Virus
Viruses, 2022 The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it possible to ...
Sergei N. Shchelkunov +11 more
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Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More
Pathogens, 2022 Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate species. The large genomes of poxviruses contain numerous genes that allow these viruses to successfully establish infection, including those that help evade the ...
Robert J. Ingham +2 more
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Journal of Medical Science, 2022 Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health ...
Dženan Kovačić, Adna Salihović
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Molecular Mechanisms of Poxvirus Evolution
mBio, 2023 Poxviruses are often thought to evolve relatively slowly because they are double-stranded DNA pathogens with proofreading polymerases. However, poxviruses have highly adaptable genomes and can undergo relatively rapid genotypic and phenotypic change, as ...
Greg Brennan +8 more
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Pathogens, 2020 The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host ...
Pragyesh Dhungel +3 more
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Frontiers in Microbiology, 2023 The monkeypox virus (MPXV) has become a major threat due to the increasing global caseload and the ongoing multi-country outbreak in non-endemic territories.
Pallavi Gulati +3 more
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