Results 51 to 60 of about 10,498 (172)

Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond

Pathogens, 2020
The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host ...
Pragyesh Dhungel, Fernando M. Cantu, Joshua A. Molina, Zhilong Yang   +3 more
doaj   +1 more source

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species

Vaccines
Background: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Huibin Yu, Mary Eloise L. Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi, Stefan Rothenburg   +6 more
doaj   +1 more source

The Global Health Threat of Monkeypox Virus: Understanding Its Biology, Transmission, and Potential Therapeutic Interventions

Infection and Drug Resistance, 2023
Yan He,1,* Ying Tang,2,* Caiyun Wang,3 Zilie Zhou,3 Wei Li,4 Man Tian3 1Department of Infection Management, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, People’s Republic of China; 2Department of Ultrasound Diagnostic, Children’s Hospital of ...
He Y, Tang Y, Wang C, Zhou Z, Li W, Tian M   +5 more
doaj  

Stress Beyond Translation: Poxviruses and More

, 2016
Poxviruses are large double-stranded DNA viruses that form viral factories in the cytoplasm of host cells. These viruses encode their own transcription machinery, but rely on host translation for protein synthesis. Thus, poxviruses have to cope with and,
Jason Liem, Jia Liu
core   +1 more source

Identification of a Potential Entry-Fusion Complex Based on Sequence Homology of African Swine Fever and Vaccinia Virus

Viruses
African swine fever virus (ASFV) belongs to the family of Asfarviridae, part of the group of nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take place at
Jesús Urquiza, Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Óscar Fernández, Ana del Puerto, José Fernando Díaz, Covadonga Alonso   +6 more
doaj   +1 more source

Nodular Dermatitis: Emergence of Novel Poxviral Infection in Russia

Проблемы особо опасных инфекций, 2018
Nodular dermatitis, (dermatitis nodularis), is an exotic for the Russian Federation poxviral disease. Some epizootical characteristics of it, problems of laboratory diagnostics, and possible reasons of extension of agent spread areal are discussed in ...
S. V. Borisevich, T. E. Sizikova, A. A. Petrov, A. V. Karulin, V. N. Lebedev   +4 more
doaj   +1 more source

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion

Viruses
Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati, Jeannine N. Stroup, Chorong Park, Taylor Clarkson, Loubna Tazi, Greg Brennan, Stefan Rothenburg   +6 more
doaj   +1 more source

The evolutionary biology of poxviruses [PDF]

Infection, Genetics and Evolution, 2010
The poxviruses (family Poxviridae) are a family of double-stranded viruses including several species that infect humans and their domestic animals, most notably Variola virus (VARV), the causative agent of smallpox. The evolutionary biology of these viruses poses numerous questions, for which we have only partial answers at present.
Austin L, Hughes, Stephanie, Irausquin, Robert, Friedman   +2 more
openaire   +2 more sources

From actually toxic to highly specific – novel drugs against poxviruses [PDF]

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Schnierle Barbara, Sliva Katja, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

TNF Decoy Receptors Encoded by Poxviruses

, 2021
Tumour necrosis factor (TNF) is an inflammatory cytokine produced in response to viral infections that promotes the recruitment and activation of leukocytes to sites of infection.
Álvarez-de Miranda, Francisco J., Alcamí, Antonio, Hernáez, Bruno, Antonio Alcamí, Isabel Alonso-Sánchez, Alonso-Sánchez, Isabel, Francisco Javier Alvarez-de Miranda, Bruno Hernaez   +7 more
core   +1 more source