Results 61 to 70 of about 10,656 (197)
The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host ...
Pragyesh Dhungel +3 more
doaj +1 more source
An integrated workflow for Mycoplasma detection and removal from cell cultures and viral stocks
Abstract Contamination of cell cultures and viral stocks with Mycoplasma is one of the most frequent and underdiagnosed problems in laboratories working with these materials, severely affecting experimental reproducibility, data reliability, and biosafety.
Eliza Flores‐Souza +8 more
wiley +1 more source
Vaccinia virus replication is not affected by APOBEC3 family members [PDF]
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +17 more
core +1 more source
African swine fever virus (ASFV) belongs to the family of Asfarviridae, part of the group of nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take place at
Jesús Urquiza +6 more
doaj +1 more source
Bacteria evolved anti‐phage systems such as Gabija defence that degrade the intracellular phage genome. Phages evolved counter‐defences such as the Gad1 protein which surrounds and inhibits the Gabija defence complex allowing phage replication. Many cases of phage anti‐defences were recently described.
Harald Brüssow
wiley +1 more source
Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley +1 more source
Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati +6 more
doaj +1 more source
Nodular Dermatitis: Emergence of Novel Poxviral Infection in Russia
Nodular dermatitis, (dermatitis nodularis), is an exotic for the Russian Federation poxviral disease. Some epizootical characteristics of it, problems of laboratory diagnostics, and possible reasons of extension of agent spread areal are discussed in ...
S. V. Borisevich +4 more
doaj +1 more source
Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang +7 more
wiley +1 more source
Recombinant poxviruses are important tools for research and some are candidate vaccines. To make these viruses a simple, small vector that can be used to engineer multiple strains of vaccinia virus and other model poxviruses, including ectromelia virus ...
Smith, Stewart +4 more
core +1 more source

