Results 41 to 50 of about 10,656 (197)

Virulent poxviruses inhibit DNA sensing by preventing STING activation [PDF]

, 2018
Cytosolic recognition of DNA has emerged as a critical cellular mechanism of host immune activation upon pathogen invasion. The central cytosolic DNA sensor cGAS activates STING, which is phosphorylated, dimerises and translocates from the ER to a ...
Carlos Maluquer de Motes, Rebecca P. Sumner, Georgana, Iliana, Greg J. Towers, Maluquer de Motes, C, Towers, GJ, Sumner, RP, Georgana, I, Maluquer de Motes, Carlos, Towers, Greg J., Iliana Georgana, Sumner, Rebecca P.   +11 more
core   +2 more sources

The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1 [PDF]

, 2010
Includes bibliographical references (leaves 131-137).Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus ...
Hu, Nai-Chung
core   +1 more source

A novel and sensitive real-time PCR system for universal detection of poxviruses

, 2021
An Author Correction to this article was published on 08 April 2022: https://www.nature.com/articles/s41598-022-09876-5International audienceSuccess in smallpox eradication was enabled by the absence of non-human reservoir for smallpox virus.
Luciani, Léa, Peyrefitte, Christophe, Piorkowski, Géraldine, Inchauste, Lucia, Nougairède, Antoine, Bertagnoli, Stéphane, de Lamballerie, Xavier, Ferraris, Olivier, Priet, Stéphane, Charrel, Rémi, Olivier Ferraris, Léa Luciani, Stéphane Bertagnoli, Lucia Inchauste, Antoine Nougairède, Géraldine Piorkowski, Xavier de Lamballerie, Christophe Peyrefitte, Rémi Charrel, Stéphane Priet   +19 more
core   +1 more source

Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R

Viruses, 2022
Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman, Loubna Tazi, Sherry L. Haller, Stefan Rothenburg   +3 more
doaj   +1 more source

Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity
The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health issues. Poxviruses, a vast family of DNA viruses, can infect many hosts, including animals and humans. The Middle East has had multiple
Laith N. AL-Eitan, Haneen O. Ali, Hana S. Abu Kharmah, Maryam K. Alasmar, Iliya Y. Khair, Ahmad H. Mihyar   +5 more
doaj   +1 more source

Enhancing the Immunogenicity of Vaccinia Virus

Viruses, 2022
The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it possible to ...
Sergei N. Shchelkunov, Stanislav N. Yakubitskiy, Alexander A. Sergeev, Ekaterina V. Starostina, Ksenia A. Titova, Stepan A. Pyankov, Galina A. Shchelkunova, Mariya B. Borgoyakova, Alexey M. Zadorozhny, Lyubov A. Orlova, Denis N. Kisakov, Larisa I. Karpenko   +11 more
doaj   +1 more source

Probe‐Free, Primer‐Programmed Amplicon Encoding Enables Nanopore‐Based Multiplex Detection With Deep Learning Decoding

Advanced Science, EarlyView.
Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed, Muhammad Asad Ullah Khalid, Wahid Uz Zaman, Anthony J. Politza, Weihua Guan   +4 more
wiley   +1 more source

Suppression of Poxvirus Replication by Resveratrol

Frontiers in Microbiology, 2017
Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents.
Shuai Cao, Susan Realegeno, Anil Pant, Panayampalli S. Satheshkumar, Zhilong Yang   +4 more
doaj   +1 more source

Efficient Cell Removal and Impurity Reduction for Poxvirus Purification in a Single Step Alluvial Filtration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modified Vaccinia virus Ankara (MVA) is a potent vector for the development of vaccines and novel cancer treatment strategies. Since it is a non‐replicating virus in human recipients, high infective titers are required for therapeutic efficacy.
Linus G. Weber, Caroline Stephan, Georgios Makris, Leander John, Ingo Jordan, Michael W. Wolff   +5 more
wiley   +1 more source

Pietro Verri: The History of Smallpox Vaccination Through His Pencil

JEADV Clinical Practice, EarlyView.
ABSTRACT The last case of natural smallpox infection occurred in 1977, and the disease is considered eradicated since 1980. Throughout the history of medicine, early attempts to combat smallpox involved inoculation, a practice based on the observation that those who recovered from the disease became immune.
Omar Simonetti, Anna Maria Salvadè, Verena Zerbato, Ivo Maria Crosato, Stefano Di Bella, Francesco Bellinato   +5 more
wiley   +1 more source