Results 41 to 50 of about 10,498 (172)

Vaccinia virus replication is not affected by APOBEC3 family members [PDF]

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source

Poxviruses

, 2010
Poxviruses are large, complex DNA viruses that have played several seminal roles in medicine and biological science. Cowpox virus was introduced by Jenner as the first human vaccine in 1796; widespread vaccination with vaccinia virus led to the global eradication of smallpox in 1977, the only human disease to have been eradicated....
Jessica Clark, Dayna Diven
  +4 more sources

Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R

Viruses, 2022
Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman, Loubna Tazi, Sherry L. Haller, Stefan Rothenburg   +3 more
doaj   +1 more source

Host-derived pathogenicity islands in poxviruses [PDF]

, 2005
BioMed CentralBackground Poxviruses are important both as pathogens and as vaccine vectors. Poxvirus genomes (150–350 kb) consist of a single linear dsDNA molecule; the two polynucleotide strands are joined by short hairpin loops.
Da Silva, Melissa, Upton, Chris
core   +2 more sources

Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity
The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health issues. Poxviruses, a vast family of DNA viruses, can infect many hosts, including animals and humans. The Middle East has had multiple
Laith N. AL-Eitan, Haneen O. Ali, Hana S. Abu Kharmah, Maryam K. Alasmar, Iliya Y. Khair, Ahmad H. Mihyar   +5 more
doaj   +1 more source

Enhancing the Immunogenicity of Vaccinia Virus

Viruses, 2022
The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it possible to ...
Sergei N. Shchelkunov, Stanislav N. Yakubitskiy, Alexander A. Sergeev, Ekaterina V. Starostina, Ksenia A. Titova, Stepan A. Pyankov, Galina A. Shchelkunova, Mariya B. Borgoyakova, Alexey M. Zadorozhny, Lyubov A. Orlova, Denis N. Kisakov, Larisa I. Karpenko   +11 more
doaj   +1 more source

Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways [PDF]

, 2009
Post-translational polypeptide tagging by conjugation with ubiquitin and ubiquitin-like (Ub/Ubl) molecules is a potent way to alter protein functions and/or sort specific protein targets to the proteasome for degradation.
Nancy Y. Villa, Villa, Nancy Y., McFadden, Grant, Zhang, Leiliang, Leiliang Zhang, Grant McFadden   +5 more
core   +1 more source

Suppression of Poxvirus Replication by Resveratrol

Frontiers in Microbiology, 2017
Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents.
Shuai Cao, Susan Realegeno, Anil Pant, Panayampalli S. Satheshkumar, Zhilong Yang   +4 more
doaj   +1 more source

Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More

Pathogens, 2022
Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate species. The large genomes of poxviruses contain numerous genes that allow these viruses to successfully establish infection, including those that help evade the ...
Robert J. Ingham, Farynna Loubich Facundo, Jianing Dong   +2 more
doaj   +1 more source

Evolution and diversity of nucleotide and dinucleotide composition in poxviruses

, 2023
International audiencePoxviruses (family Poxviridae) have long dsDNA genomes and infect a wide range of hosts, including insects, birds, reptiles and mammals.
Molteni, Cristian, Forni, Diego, Bravo, Ignacio G., Cristian Molteni, Ignacio G. Bravo, Cagliani, Rachele, Manuela Sironi, Diego Forni, Rachele Cagliani, Sironi, Manuela   +9 more
core   +1 more source