Results 41 to 50 of about 9,912 (196)

Cidofovir Activity against Poxvirus Infections

Viruses, 2010
Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC] is an acyclic nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
Robert Snoeck, Graciela Andrei
doaj   +1 more source

Tattoo Skin Disease in Cetacea: A Review, with New Cases for the Northeast Pacific

Animals, 2022
Tattoo skin disease (TSD) is a poxviral dermatopathy diagnosed in cetaceans. We review the literature on TSD aetiology, clinical characteristics, pathology and epidemiology and evaluate immune responses against the virus.
Marie-Françoise Van Bressem, Koen Van Waerebeek, Pádraig J. Duignan   +2 more
doaj   +1 more source

Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity
The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health issues. Poxviruses, a vast family of DNA viruses, can infect many hosts, including animals and humans. The Middle East has had multiple
Laith N. AL-Eitan, Haneen O. Ali, Hana S. Abu Kharmah, Maryam K. Alasmar, Iliya Y. Khair, Ahmad H. Mihyar   +5 more
doaj   +1 more source

Suppression of Poxvirus Replication by Resveratrol

Frontiers in Microbiology, 2017
Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents.
Shuai Cao, Susan Realegeno, Anil Pant, Panayampalli S. Satheshkumar, Zhilong Yang   +4 more
doaj   +1 more source

Nano‐Silver‐Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Exploration, EarlyView.
There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang, Mengjun Li, Zining Liu, Jiayin Chen, Ke Liu, Fengfang Wei, Junrui Li, Yixuan Xie, Yushan Jiang, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Minghui Yang, Hua Ma, Ruilin Zhang, Chenguang Shen, Yuhui Liao   +15 more
wiley   +1 more source

Evolution and diversity of nucleotide and dinucleotide composition in poxviruses

, 2023
International audiencePoxviruses (family Poxviridae) have long dsDNA genomes and infect a wide range of hosts, including insects, birds, reptiles and mammals.
Molteni, Cristian, Forni, Diego, Bravo, Ignacio G., Cristian Molteni, Ignacio G. Bravo, Cagliani, Rachele, Manuela Sironi, Diego Forni, Rachele Cagliani, Sironi, Manuela   +9 more
core   +1 more source

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species

Vaccines
Background: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Huibin Yu, Mary Eloise L. Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi, Stefan Rothenburg   +6 more
doaj   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Treatments for Molluscum contagiosum: A systematic review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Molluscum contagiosum (MC) is a viral skin infection that poses significant physical and psychosocial burdens, particularly in pediatric and immunocompromised populations. Despite the availability of various treatment options, comparative efficacy and safety data remain limited.
Ou Jia (Emilie) Wang, Mahek Shergill, Ammar Saed Aldien, Ilya Mukovozov   +3 more
wiley   +1 more source

Identification of a Potential Entry-Fusion Complex Based on Sequence Homology of African Swine Fever and Vaccinia Virus

Viruses
African swine fever virus (ASFV) belongs to the family of Asfarviridae, part of the group of nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take place at
Jesús Urquiza, Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Óscar Fernández, Ana del Puerto, José Fernando Díaz, Covadonga Alonso   +6 more
doaj   +1 more source