Antagonism of Protein Kinase R by Large DNA Viruses. [PDF]
Pathogens, 2022 Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis.
Olson AT, Child SJ, Geballe AP.
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The protein kinase R modifies gut physiology to limit colitis. [PDF]
Front Immunol, 2023 Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transgenic ...
Yim HCH +10 more
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Protein Kinase R in Bacterial Infections: Friend or Foe? [PDF]
Front Immunol, 2021 The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative treatment strategies to combat ...
Smyth R, Sun J.
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Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R. [PDF]
Viruses, 2022 Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
Rahman MJ +3 more
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The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration. [PDF]
Front Aging Neurosci, 2021 There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates.
Martinez NW, Gómez FE, Matus S.
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The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage. [PDF]
Brain Behav, 2022 Purpose: To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)‐mediated ferroptosis. Methods: A rat SAH model was constructed and treated with PKR inhibitor C16 to observe SAH and neurological impairment in rats
Lei J +5 more
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Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs. [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Park C +6 more
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Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis. [PDF]
J VirolProtein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli.
Edwards Iii DF +5 more
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Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R. [PDF]
Saudi Pharm J, 2021 This study examined if the Fisetin against streptozotocin-induced diabetic cardiomyopathy (DC) in rats involves regulating cardiac metabolism and suppressing protein kinase R (PKR).
ALTamimi JZ +5 more
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Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion. [PDF]
VirusesYaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Megawati D +6 more
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