Antagonism of Protein Kinase R by Large DNA Viruses [PDF]
Pathogens, 2022 Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis.
Annabel T. Olson +2 more
doaj +4 more sources
The protein kinase R modifies gut physiology to limit colitis [PDF]
Frontiers in Immunology, 2023 Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transgenic ...
Howard Chi Ho Yim +18 more
doaj +5 more sources
Protein Kinase R in Bacterial Infections: Friend or Foe? [PDF]
Frontiers in Immunology, 2021 The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative treatment strategies to combat ...
Robin Smyth, Jim Sun, Jim Sun
doaj +5 more sources
Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R [PDF]
Viruses, 2022 Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman +3 more
doaj +6 more sources
The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2021 There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates.
Nicolás W. Martinez +8 more
doaj +6 more sources
The role of protein kinase R in dystonia
Dystonia, 2023 Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd +3 more
doaj +2 more sources
The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage [PDF]
Brain and Behavior, 2022 Purpose: To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)‐mediated ferroptosis. Methods: A rat SAH model was constructed and treated with PKR inhibitor C16 to observe SAH and neurological impairment in rats
Jianwei Lei +5 more
doaj +2 more sources
Structural Basis of Protein Kinase R Autophosphorylation. [PDF]
Biochemistry, 2019 The RNA-activated protein kinase, PKR, is a key mediator of the innate immunity response to viral infection. Viral double-stranded RNAs induce PKR dimerization and autophosphorylation. The PKR kinase domain forms a back-to-back dimer. However, intermolecular ( trans) autophosphorylation is not feasible in this arrangement.
Mayo CB +6 more
europepmc +4 more sources
Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis [PDF]
Journal of VirologyProtein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli.
Daniel F. Edwards, III +5 more
doaj +2 more sources
Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park +6 more
doaj +2 more sources