Results 41 to 50 of about 23,156,384 (284)
Advanced Science, 2023 Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes,
Qian Li +12 more
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Journal of Lipid Research, 2014 Evidence suggests a causative role for endoplasmic reticulum (ER) stress in the development of atherosclerosis. This study investigated the potential role of glycogen synthase kinase (GSK)-3α/β in proatherogenic ER stress signaling.
Cameron S. McAlpine, Geoff H. Werstuck
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Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]
, 2010 The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core +1 more source
Evidence for dispensability of protein kinase R in host control of tuberculosis [PDF]
European Journal of Immunology, 2018 AbstractGenetic deficiency of protein kinase R (PKR) in mice was reported to enhance macrophage activation in vitro in response to interferon‐γ (IFNγ) and to reduce the burden of Mycobacterium tuberculosis (Mtb) in vivo (Wu et al. PloS One. 2012 7:e30512). Consistent with this, treatment of wild‐type (WT) macrophages in vitro with a novel PKR inhibitor
Shashirekha, Mundhra +5 more
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CREB Regulates AChE-R-Induced Proliferation of Human Glioblastoma Cells
Neoplasia: An International Journal for Oncology Research, 2004 The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R.
Chava Perry +2 more
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Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1 [PDF]
Journal of Virology, 2017 ABSTRACT Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replication. The HCMV pTRS1 and pIRS1 proteins antagonize PKR to promote HCMV protein synthesis and replication; however, the mechanism by which pTRS1 ...
Heather A, Vincent +2 more
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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
Neurobiology of Disease, 2019 TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS).
Thomas J. LaRocca +3 more
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A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. [PDF]
PLoS Pathogens, 2016 During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway.
Kathryn S Carpentier +3 more
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Journal of Pharmacological Sciences, 2016 Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet ...
Tetsuya Ohnou +8 more
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microPublication Biology, 2023 Changes in neuronal function that occur with age are an area of increasing importance. A potential significant contributor to age-dependent decline may be alterations to neurotransmitter release.
James R. Johnson, Jeff W. Barclay
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