Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]
, 2000 The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David +16 more
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Analysis of Monomeric and Dimeric Phosphorylated Forms of Protein Kinase R [PDF]
Biochemistry, 2010 PKR (protein kinase R) is induced by interferon and is a key component of the innate immunity antiviral pathway. Upon binding double-stranded RNA (dsRNA) or dimerization in the absence of dsRNA, PKR undergoes autophosphorylation at multiple serines and threonines that activate the kinase.
Eric, Anderson +5 more
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Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]
, 2005 Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core +1 more source
Roles of protein kinase R in cancer: Potential as a therapeutic target [PDF]
Cancer Science, 2018 Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein induced by interferon (IFN) and activated by dsRNA. PKR is recognized as a key executor of antiviral host defense.
Takao Watanabe +2 more
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Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]
, 2012 eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat +16 more
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Protein Kinase R Is Responsible for the Phosphorylation of eIF2α in Rotavirus Infection [PDF]
Journal of Virology, 2010 ABSTRACT The eukaryotic initiation translation factor 2 (eIF2) represents a key point in the regulation of protein synthesis. This factor delivers the initiator Met-tRNA to the ribosome, a process that is conserved in all eukaryotic cells. Many types of stress reduce global translation by triggering the phosphorylation of the α subunit of ...
Margarito, Rojas +2 more
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KIF14 and citron kinase act together to promote efficient cytokinesis [PDF]
, 2006 Multiple mitotic kinesins and microtubule-associated proteins (MAPs) act in concert to direct cytokinesis (Glotzer, M. 2005. Science. 307:1735-1739). In anaphase cells, many of these proteins associate with an antiparallel array of microtubules termed ...
Erich A. Nigg +13 more
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ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C
Медицинская иммунология, 2014 . Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C.
V. A. Bychkov +5 more
doaj +1 more source
Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]
, 2014 The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen +3 more
core +1 more source
mBio, 2010 Overwhelming inflammation triggered by systemic infection in bacterial sepsis contributes to the pathology of this condition. Toll-like receptors (TLRs) are important in early septic inflammation.
Darren J. Perkins +2 more
doaj +1 more source