The role of protein kinase R in dystonia
Dystonia, 2023 Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd +3 more
doaj +2 more sources
Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells. [PDF]
J Virus EradEvaluation of CD4 T cell status in early HIV infection is critical for developing strategies targeting HIV replication. In this study, we infected CD4 T cells with HIV-1 and investigated the cell survival mechanisms in HIV-infected versus uninfected ...
Pyburn J +14 more
europepmc +2 more sources
Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy. [PDF]
Front Microbiol, 2020 Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Smyth R +4 more
europepmc +2 more sources
Essential role of protein kinase R in the pathogenesis of pulmonary veno-occlusive disease. [PDF]
JCI InsightPulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension, characterized by progressive remodeling of small pulmonary arteries and veins with no therapies. Using a mitomycin C–induced (MMC-induced) rat model,
Prabhakar A +12 more
europepmc +2 more sources
Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury [PDF]
Respiratory Research, 2018 Background Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure.
Tamás Dolinay +12 more
doaj +5 more sources
Structural Basis of Protein Kinase R Autophosphorylation. [PDF]
Biochemistry, 2019 The RNA-activated protein kinase, PKR, is a key mediator of the innate immunity response to viral infection. Viral double-stranded RNAs induce PKR dimerization and autophosphorylation. The PKR kinase domain forms a back-to-back dimer. However, intermolecular ( trans) autophosphorylation is not feasible in this arrangement.
Mayo CB +6 more
europepmc +4 more sources
Increasing lentiviral vector titer using inhibitors of protein kinase R [PDF]
BioTechniques, 2004 Lentiviral Production Looks Up Stable gene transfer methods increasingly involve lentiviral vectors because of the vector's large cloning capacity, stable integration into the host genome, and easy...
Gilles Pernod +3 more
doaj +5 more sources
Structural instability in an autophosphorylating kinase switch [PDF]
, 2009 We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into ...
Grinfeld, M., Webb, S.D.
core +4 more sources
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]
, 2014 Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf +8 more
core +3 more sources
Dual Activators of Protein Kinase R (PKR) and Protein Kinase R‐Like Kinase (PERK) Identify Common and Divergent Catalytic Targets [PDF]
ChemBioChem, 2013 AbstractChemical genetics has evolved into a powerful tool for studying gene function in normal and pathobiology. PKR and PERK, two eukaryotic translation initiation factor 2 alpha (eIF2α) kinases, play critical roles in the maintenance of cellular hemostasis, metabolic stability, and anti‐viral defenses.
Huijun, Bai +9 more
openaire +2 more sources