Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R [PDF]
Saudi Pharmaceutical Journal, 2021 This study examined if the Fisetin against streptozotocin-induced diabetic cardiomyopathy (DC) in rats involves regulating cardiac metabolism and suppressing protein kinase R (PKR).
Jozaa Z. ALTamimi +5 more
doaj +2 more sources
Increasing lentiviral vector titer using inhibitors of protein kinase R [PDF]
BioTechniques, 2004 Lentiviral Production Looks Up Stable gene transfer methods increasingly involve lentiviral vectors because of the vector's large cloning capacity, stable integration into the host genome, and easy...
Gilles Pernod +3 more
doaj +5 more sources
Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion [PDF]
VirusesYaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati +6 more
doaj +2 more sources
Protein Kinase R Is Constitutively Expressed in the Human Pancreas. [PDF]
J Histochem Cytochem, 2019 Summary Viral infection of the insulin-producing cells in the pancreas has been proposed in the etiology of type 1 diabetes. Protein kinase R (PKR) is a cytoplasmic protein activated through phosphorylation in response to cellular stress and particularly viral infection.
Jonsson A +5 more
europepmc +4 more sources
Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy [PDF]
Frontiers in Microbiology, 2021 Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Robin Smyth +5 more
doaj +2 more sources
Essential role of protein kinase R in the pathogenesis of pulmonary veno-occlusive disease [PDF]
JCI InsightPulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension, characterized by progressive remodeling of small pulmonary arteries and veins with no therapies. Using a mitomycin C–induced (MMC-induced) rat model,
Amit Prabhakar +12 more
doaj +2 more sources
Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells [PDF]
Journal of Virus EradicationEvaluation of CD4 T cell status in early HIV infection is critical for developing strategies targeting HIV replication. In this study, we infected CD4 T cells with HIV-1 and investigated the cell survival mechanisms in HIV-infected versus uninfected ...
Jaeden Pyburn +14 more
doaj +2 more sources
Confirming the importance of the R-spine: new insights into protein kinase regulation. [PDF]
PLoS Biology, 2013 PhosphorylationPhosphorylation is a ubiquitous means of changing a protein's behavior. Adding a phosphate group to a serine, threonine, or tyrosine amino acid alters the shape and charge of the protein, a change that may activate an enzyme, promote membrane translocation, or trigger binding to DNA.
Richard Robinson
doaj +4 more sources
Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury [PDF]
Respiratory Research, 2018 Background Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure.
Tamás Dolinay +12 more
doaj +5 more sources
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]
, 2014 Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf +8 more
core +3 more sources