Results 21 to 30 of about 23,156,384 (284)

Protein Kinase R Is Constitutively Expressed in the Human Pancreas. [PDF]

J Histochem Cytochem, 2019
Summary Viral infection of the insulin-producing cells in the pancreas has been proposed in the etiology of type 1 diabetes. Protein kinase R (PKR) is a cytoplasmic protein activated through phosphorylation in response to cellular stress and particularly viral infection.
Jonsson A, Yngve E, Karlsson M, Ingvast S, Skog O, Korsgren O.   +5 more
europepmc   +4 more sources

Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo

Poultry Science, 2023
: This study aimed to investigate whether the developmental changes in glucose metabolism were associated with insulin signaling in the middle and later stages of goose embryos.
H. Wang, Y.W. Zhu, J. Yang, X.Y. Wang, Y.C. Zhan, W.C. Wang, L. Yang   +6 more
doaj   +1 more source

Binding and Relocalization of Protein Kinase R by Murine Cytomegalovirus [PDF]

Journal of Virology, 2009
ABSTRACT Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor 2α.
Stephanie J, Child, Adam P, Geballe
openaire   +2 more sources

Auto-phosphorylation Represses Protein Kinase R Activity [PDF]

Scientific Reports, 2017
AbstractThe central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively target these different states of kinases to repress their activation.
Wang, D, de Weerd, NA, Willard, B, Polekhina, G, Williams, BRG, Sadler, AJ   +5 more
openaire   +3 more sources

Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model

Cardiovascular Therapeutics, 2022
Objective. Remote ischemic conditioning (RIC) is a cardioprotective method in ischemia/reperfusion (I/R) injury. This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods.
Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu   +8 more
doaj   +1 more source

Confirming the importance of the R-spine: new insights into protein kinase regulation. [PDF]

PLoS Biology, 2013
​PhosphorylationPhosphorylation is a ubiquitous means of changing a protein's behavior. Adding a phosphate group to a serine, threonine, or tyrosine amino acid alters the shape and charge of the protein, a change that may activate an enzyme, promote membrane translocation, or trigger binding to DNA.
Richard Robinson
doaj   +4 more sources

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis [PDF]

Nature Chemical Biology, 2013
Formation of the inflammasome, a scaffolding complex that activates caspase-1, is important in numerous diseases. Pyroptotic cell death induced by anthrax lethal toxin (LT) is a model for inflammasome-mediated caspase-1 activation. We discovered 7-desacetoxy-6,7-dehydrogedunin (7DG) in a phenotypic screen as a small molecule that protects macrophages ...
Hett, Erik C, Slater, Louise H, Mark, Kevin G, Kawate, Tomohiko, Monks, Brian G, Stutz, Andrea, Latz, Eicke, Hung, Deborah T   +7 more
openaire   +5 more sources

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development [PDF]

The FEBS Journal, 2015
The murine double‐stranded RNA‐binding protein termed protein kinase R (PKR)‐associated protein X (RAX) and the human homolog, protein activator of PKR (PACT), were originally characterized as activators of PKR. Mice deficient in RAX show reproductive and developmental defects, including reduced body size, craniofacial defects and anterior pituitary ...
Benjamin K, Dickerman, Christine L, White, Patricia M, Kessler, Anthony J, Sadler, Bryan R G, Williams, Ganes C, Sen   +5 more
openaire   +2 more sources

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 ...
Swati Gupta, Kamla Prasad Mishra, Paban Kumar Dash, Manmohan Parida, Lilly Ganju, Shashi Bala Singh   +5 more
doaj   +1 more source