Results 21 to 30 of about 18,219,543 (287)

Dual Activators of Protein Kinase R (PKR) and Protein Kinase R‐Like Kinase (PERK) Identify Common and Divergent Catalytic Targets [PDF]

ChemBioChem, 2013
AbstractChemical genetics has evolved into a powerful tool for studying gene function in normal and pathobiology. PKR and PERK, two eukaryotic translation initiation factor 2 alpha (eIF2α) kinases, play critical roles in the maintenance of cellular hemostasis, metabolic stability, and anti‐viral defenses.
Huijun, Bai, Ting, Chen, Jie, Ming, Hong, Sun, Peng, Cao, Dahlene N, Fusco, Raymond T, Chung, Michael, Chorev, Qi, Jin, Bertal H, Aktas   +9 more
openaire   +2 more sources

Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo

Poultry Science, 2023
: This study aimed to investigate whether the developmental changes in glucose metabolism were associated with insulin signaling in the middle and later stages of goose embryos.
H. Wang, Y.W. Zhu, J. Yang, X.Y. Wang, Y.C. Zhan, W.C. Wang, L. Yang   +6 more
doaj   +1 more source

Auto-phosphorylation Represses Protein Kinase R Activity [PDF]

Scientific Reports, 2017
AbstractThe central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively target these different states of kinases to repress their activation.
Wang, D, de Weerd, NA, Willard, B, Polekhina, G, Williams, BRG, Sadler, AJ   +5 more
openaire   +3 more sources

Binding and Relocalization of Protein Kinase R by Murine Cytomegalovirus [PDF]

Journal of Virology, 2009
ABSTRACT Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor 2α.
Stephanie J, Child, Adam P, Geballe
openaire   +2 more sources

Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model

Cardiovascular Therapeutics, 2022
Objective. Remote ischemic conditioning (RIC) is a cardioprotective method in ischemia/reperfusion (I/R) injury. This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods.
Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu   +8 more
doaj   +1 more source

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis [PDF]

Nature Chemical Biology, 2013
Formation of the inflammasome, a scaffolding complex that activates caspase-1, is important in numerous diseases. Pyroptotic cell death induced by anthrax lethal toxin (LT) is a model for inflammasome-mediated caspase-1 activation. We discovered 7-desacetoxy-6,7-dehydrogedunin (7DG) in a phenotypic screen as a small molecule that protects macrophages ...
Hett, Erik C, Slater, Louise H, Mark, Kevin G, Kawate, Tomohiko, Monks, Brian G, Stutz, Andrea, Latz, Eicke, Hung, Deborah T   +7 more
openaire   +5 more sources

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

Analysis of Monomeric and Dimeric Phosphorylated Forms of Protein Kinase R [PDF]

Biochemistry, 2010
PKR (protein kinase R) is induced by interferon and is a key component of the innate immunity antiviral pathway. Upon binding double-stranded RNA (dsRNA) or dimerization in the absence of dsRNA, PKR undergoes autophosphorylation at multiple serines and threonines that activate the kinase.
Eric, Anderson, Christine, Quartararo, Raymond S, Brown, Yu, Shi, Xudong, Yao, James L, Cole   +5 more
openaire   +2 more sources

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 ...
Swati Gupta, Kamla Prasad Mishra, Paban Kumar Dash, Manmohan Parida, Lilly Ganju, Shashi Bala Singh   +5 more
doaj   +1 more source

Roles of protein kinase R in cancer: Potential as a therapeutic target [PDF]

Cancer Science, 2018
Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein induced by interferon (IFN) and activated by dsRNA. PKR is recognized as a key executor of antiviral host defense.
Takao Watanabe, Takeshi Imamura, Yoichi Hiasa   +2 more
openaire   +2 more sources