Results 1 to 10 of about 1,111 (183)

Antagonism of Protein Kinase R by Large DNA Viruses [PDF]

Pathogens, 2022
Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis.
Annabel T. Olson, Stephanie J. Child, Adam P. Geballe   +2 more
doaj   +2 more sources

Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats [PDF]

Frontiers in Immunology, 2021
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell, Sathya N. Thulasi Raman, Caroline Gravel, Wanyue Zhang, Wanyue Zhang, Annabelle Pfeifle, Annabelle Pfeifle, Wangxue Chen, Gary Van Domselaar, David Safronetz, Michael Johnston, Michael Johnston, Simon Sauve, Lisheng Wang, Michael Rosu-Myles, Michael Rosu-Myles, Jingxin Cao, Xuguang Li, Xuguang Li   +18 more
doaj   +2 more sources

Insights into molecular mechanisms of poxvirus evolution and host range through studies of poxvirus inhibitors of protein kinase R [PDF]

Journal of Virology
Protein kinase R (PKR) acts both as a sensor for virus infections, by detecting double-stranded (ds) RNA, and as an antiviral effector by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Stefan Rothenburg, Dewi Megawati, Ryan Bruneau, Loubna Tazi   +3 more
doaj   +2 more sources

Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
In this paper, we describe the stepwise development of a cell-free protein synthesis (CFPS) platform derived from cultured Chinese hamster ovary (CHO) cells.
Chiara Heide, Chiara Heide, Chiara Heide, Gizem Buldum, Ignacio Moya-Ramirez, Ignacio Moya-Ramirez, Oscar Ces, Oscar Ces, Cleo Kontoravdi, Karen M. Polizzi, Karen M. Polizzi   +10 more
doaj   +2 more sources

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion [PDF]

Viruses
Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati, Jeannine N. Stroup, Chorong Park, Taylor Clarkson, Loubna Tazi, Greg Brennan, Stefan Rothenburg   +6 more
doaj   +2 more sources

Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]

Viruses
Protein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park, Greg Brennan, Chen Peng, Chi Zhang, Jingxin Cao, Loubna Tazi, Stefan Rothenburg   +6 more
doaj   +2 more sources

Application of poxvirus K3 ortholog as a positive selection marker for constructing recombinant vaccinia viruses with modified host range [PDF]

MethodsX, 2020
Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao, Christine Layne, Jessie Varga, Yvon Deschambault   +3 more
doaj   +2 more sources

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic [PDF]

eLife
Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued.
Michael James Chambers, Sophia B Scobell, Meru J Sadhu   +2 more
doaj   +2 more sources

Profil Buruh K3L Zona 2 Universitas Padjadjaran

Prosiding Penelitian Dan Pengabdian Kepada Masyarakat, 2018
Peningkatan jumlah penduduk usia kerja pada tahun 2010 mengakibatkan penurunan pada beban ketergantungan. Dengan banyaknya penduduk pada usia produktif menjadikan Indonesia memiliki pasar tenaga kerja yang besar. Seiring dengan perkembangan zaman, kebutuhan manusia semakin meningka, begitu juga pekerja/buruh.
Aulia Vegianti, Nurliana Cipta Apsari
exaly   +3 more sources

The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range

Virology, 2002
Vaccinia virus encodes two regulators of the cellular antiviral response. The E3L gene is thought to act primarily by sequestering double-stranded RNA, whereas the K3L gene is thought to act as a competitive inhibitor of the double-stranded RNA-dependent protein kinase, PKR.
Bertram L Jacobs
exaly   +3 more sources