Paleodepositional environment and salt lake organic matter enrichment model of the Paleogene Linhe Formation in the Linhe Sag of the Hetao Basin [PDF]
E3S Web of Conferences, 2023 The well-developed mudstone and gypsum mudstone in Oligocene Linhe Formation (E3l) in the Hetao Basin are the main source rocks. However, the sedimentary environment and organic matter (OM) enrichment factors of E3l are not clear, which inhibit the ...
Wei Liu
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Insights into molecular mechanisms of poxvirus evolution and host range through studies of poxvirus inhibitors of protein kinase R [PDF]
Journal of VirologyProtein kinase R (PKR) acts both as a sensor for virus infections, by detecting double-stranded (ds) RNA, and as an antiviral effector by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Stefan Rothenburg +3 more
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Comparative Genomic Analysis of Two Bat Poxviruses in the Genus Vespertilionpoxvirus [PDF]
VirusesPoxviruses are large double-stranded DNA (dsDNA) viruses that cause important human and animal diseases, including smallpox and mpox. Poxviruses have also been identified in diverse bat populations; however, their potential for zoonotic transmission and ...
Chi Zhang +4 more
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Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses [PDF]
Viruses, 2023 Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the ...
Fauziah Mohd Jaafar +5 more
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A cocktail vaccine with monkeypox virus antigens confers protection without selecting mutations in potential immune evasion genes in the vaccinia WR strain challenge [PDF]
mBioFaced with the global monkeypox outbreak, current vaccine development predominantly focuses on the mRNA platform despite its limitations in stability and long-term efficacy.
Xintong Sun +16 more
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Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion [PDF]
VirusesYaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati +6 more
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The identification and genetic characteristics of the Orf virus strain (ORFV-CL24) isolated from Jilin province, China [PDF]
Frontiers in MicrobiologyOrf virus (ORFV), the prototype species of the Parapoxvirus genus within the Poxviridae family (subfamily Chordopoxvirinae), is a global pathogen infecting sheep, goats, and other ruminants, with zoonotic potential for humans.
Lijun Lv +9 more
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Antagonism of Protein Kinase R by Large DNA Viruses
Pathogens, 2022 Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis.
Annabel T. Olson +2 more
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Frontiers in Immunology, 2021 Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell +18 more
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The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules
Frontiers in Immunology, 2021 Both DNA and RNA can maintain left-handed double helical Z-conformation under physiological condition, but only when stabilized by Z-DNA binding domain (ZDBD).
De Chen Chiang +4 more
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