Results 11 to 20 of about 1,772 (177)

The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Journal of Diabetes Research, 2019
Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/−) mice ...
Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen   +11 more
doaj   +4 more sources

Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus [PDF]

Journal of Virology, 2002
ABSTRACT The vaccinia virus E3L gene encodes two double-stranded RNA binding proteins that promote viral growth and pathogenesis through suppression of innate immunity. To explore how E3L enables vaccinia virus to evade the interferon system, cells and mice deficient in the principal interferon-regulated antiviral enzymes, PKR and RNase L ...
Ying, Xiang, Richard C, Condit, Sangeetha, Vijaysri, Bertram, Jacobs, Bryan R G, Williams, Robert H, Silverman   +5 more
openaire   +3 more sources

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

Journal of Lipid Research, 2010
The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V)LDL.
Silvia Bijland, Sjoerd A.A van den Berg, Peter J. Voshol, Anita M. van den Hoek, Hans M.G Princen, Louis M. Havekes, Patrick C.N Rensen, Ko Willems van Dijk   +7 more
doaj   +3 more sources

Advancing Logistics Management: E3L-Net for Predictive Demand Analytics

IEEE Access
The essence of smart logistics lies in leveraging information resources and intellectual assets to efficiently and precisely match the multidimensional demands and supplies within the logistics system.
Yao Lu
doaj   +3 more sources

E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox [PDF]

Viruses, 2018
The highly attenuated Modified Vaccinia virus Ankara (MVA) lacks most of the known vaccinia virus (VACV) virulence and immune evasion genes. Today MVA can serve as a safety-tested next-generation smallpox vaccine.
Asisa Volz, Sylvia Jany, Astrid Freudenstein, Markus Lantermann, Holger Ludwig, Gerd Sutter   +5 more
doaj   +2 more sources

siRNA targeting Vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects

Virology, 2006
The Vaccinia virus gene, E3L, encodes a double-stranded RNA [dsRNA]-binding protein. We hypothesized that, owing to the critical nature of dsRNA in triggering host innate antiviral responses, E3L-specific small-interfering RNAs [siRNAs] should be effective antiviral agents against pox viruses, for which Vaccinia virus is an appropriate surrogate.
DAVE RS, MCGETTIGAN JP, QURESHI T, SCHNELL MJ, NUNNARI G, POMERANTZ RJ   +5 more
openaire   +3 more sources

Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L [PDF]

Journal of Virology, 2003
ABSTRACT Highly attenuated modified vaccinia virus Ankara (MVA) serves as a candidate vaccine to immunize against infectious diseases and cancer. MVA was randomly obtained by serial growth in cultures of chicken embryo fibroblasts (CEF), resulting in the loss of substantial genomic information including many genes regulating virus-host ...
Hornemann, Simone, Harlin, Olof, Staib, Caroline, Kisling, Sigrid, Erfle, Volker, Kaspers, Bernd, Häcker, Georg, Sutter, Gerd   +7 more
core   +4 more sources

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

Journal of Lipid Research, 2007
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester ...
Caroline C. van der Hoogt, Willeke de Haan, Marit Westerterp, Menno Hoekstra, Geesje M. Dallinga-Thie, Johannes A. Romijn, Hans M.G. Princen, J. Wouter Jukema, Louis M. Havekes, Patrick C.N. Rensen   +9 more
doaj   +2 more sources

CETP expression reverses the reconstituted HDL-induced increase in VLDL

Journal of Lipid Research, 2011
Human data suggest that reconstituted HDL (rHDL) infusion can induce atherosclerosis regression. Studies in mice indicated that rHDL infusion adversely affects VLDL levels, but this effect is less apparent in humans.
Yanan Wang, Jimmy F.P. Berbée, Erik S. Stroes, Johannes W.A. Smit, Louis M. Havekes, Johannes A. Romijn, Patrick C.N. Rensen   +6 more
doaj   +2 more sources

Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein. [PDF]

PLoS ONE, 2011
During the last decades, research focused on vaccinia virus (VACV) pathogenesis has been intensified prompted by its potential beneficial application as a vector for vaccine development and anti-cancer therapies, but also due to the fear of its potential
Susana Guerra, Fernando Abaitua, Luis Martínez-Sobrido, Mariano Esteban, Adolfo García-Sastre, Dolores Rodríguez   +5 more
doaj   +6 more sources