Results 41 to 50 of about 1,772 (177)

HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

Cell & Bioscience, 2023
Background Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation.
Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout, Raymond Kaempfer   +5 more
doaj   +1 more source

Vaccinia Virus E3L Protein Is an Inhibitor of the Interferon (IFN)-Induced 2-5A Synthetase Enzyme

Virology, 1998
Induction of apoptosis in mammalian cells by double-stranded (ds) RNA-dependent enzymes, protein kinase (PKR), and 2-5A-synthetase/RNase L (referred to as the 2-5A system) might be a mechanism mediating anticellular and antiviral actions of interferon (i.f.n.). To counteract the effect of i.f.n., animal viruses have acquired genes that block specific i.
Rivas, Carmen, Gil, Jesús, Mělková, Zora, Esteban, Mariano, Díaz-Guerra, Margarita   +4 more
openaire   +2 more sources

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, Volume 36, Issue 3, Page 2298-2308, August 2026.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

Assessing relational values of sacred landscapes through text mining of folktales: Insights from the Ryukyu Islands, Japan

People and Nature, Volume 8, Issue 7, Page 2383-2392, July 2026.
Abstract Assessing relational values of nature through its cultural and spiritual significance is crucial for effective nature conservation. Folktales offer insights into traditional relationships between people and nature, and text mining is a powerful tool for extracting information from textual datasets.
Naoki Saito, Soyo Takahashi, Akira Iguchi   +2 more
wiley   +1 more source

Distinct Patterns of IFN Sensitivity Observed in Cells Infected with Vaccinia K3L- and E3L- Mutant Viruses

Virology, 1995
Recent results have implicated a role for both the VV K3L- and E3L-encoded gene products in conferring VV with an IFN-resistant phenotype (Beattie et al., Virology 183, 419-422, 1991; Beattie et al., J. Virol. 69, 499-505, 1995). As a means of further establishing the mechanisms by which these functions mediate this process in VV-infected cells, we ...
Beattie, Elizabeth, Paoletti, Enzo, Tartaglia, James   +2 more
openaire   +2 more sources

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Suppression of Proinflammatory Signal Transduction and Gene Expression by the DualNucleic Acid Binding Domains of the Vaccinia Virus E3L Proteins [PDF]

Journal of Virology, 2006
ABSTRACT Cells have evolved elaborate mechanisms to counteract the onslaught of viral infections. To activate these defenses, the viral threat must be recognized. Danger signals, or pathogen-associated molecular patterns, that are induced by pathogens include double-stranded RNA (dsRNA), viral single-stranded RNA, glycolipids, and CpG DNA ...
Jeffrey O, Langland, John C, Kash, Victoria, Carter, Matthew J, Thomas, Michael G, Katze, Bertram L, Jacobs   +5 more
openaire   +2 more sources

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, Volume 37, Issue 3, Page 375-385, June 2026.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

The Double-stranded RNA Binding Domain of the Vaccinia Virus E3L Protein Inhibits Both RNA- and DNA-induced Activation of Interferon β

, 2009
Vaccinia virus, a large DNA virus that replicates in the cytoplasm, expresses its E3L protein to inhibit the cellular innate immune response and apoptosis. E3L is a bifunctional protein that contains an N-terminal DNA binding domain (BD) and a C-terminal
Luban, Jeremy, Jean-Baptiste Marq, Daniel Kolakofsky, Marq, Jean-Baptiste, Hausmann, Stéphane, Garcin, Dominique, Dominique Garcin, Kolakofsky, Daniel, Jeremy Luban, Stéphane Hausmann, Luban J, Marq JB, Hausmann S, Garcin D, Kolakofsky D   +14 more
core   +1 more source

Generation cycles in experimental populations of a multivoltine insect

Journal of Animal Ecology, Volume 95, Issue 5, Page 782-794, May 2026.
Although theory suggests various mechanisms by which environmental and ecological factors may drive generational fluctuations, our field‐cage experiment is the first to demonstrate how internal dynamics and external disturbances jointly produce synchronised, large‐scale outbreak cycles.
Takehiko Yamanaka, Yasushi Sato, William A. Nelson, Ottar N. Bjørnstad   +3 more
wiley   +1 more source