Results 21 to 30 of about 1,772 (177)
Identification of host proteins which interact with vaccinia virus encoded E3L
, 1999 The E3L protein is one of a number of proteins encoded by Vaccinia Virus (VV) which antagonise the IFN cellular response. E3L is a dsRNA binding protein which sequesters dsRNA that would ordinarily activate PKR.
Sarah J. Rogan (7691357)
core +6 more sources
MethodsX, 2020 Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao +3 more
doaj +1 more source
Complementation of Vaccinia Virus Deleted of the E3L Gene by Mutants of E3L
Virology, 1997 Vaccinia virus devoid of its E3L gene is sensitive to treatment of RK-13 cells with interferon-alpha and fails to replicate or form plaques in HeLa cells. In order to determine function of the E3L gene, vaccinia virus recombinants were constructed by inserting mutant E3L genes or a gene coding for an alternative dsRNA-binding protein into virus deleted
Shors, Teri +5 more
openaire +2 more sources
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response
Biomedicines, 2022 Poxviridae have developed a plethora of strategies to evade innate and adaptive immunity. In this review, we focused on the vaccinia virus E3 protein, encoded by the E3L gene. E3 is present within the Chordopoxvirinae subfamily (with the exception of the
Mateusz Szczerba +5 more
doaj +1 more source
Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L
Virology, 2004 The process of eukaryotic translation initiation can be regulated by a highly conserved mechanism involving the phosphorylation of the translation initiation factor eIF2 on the alpha subunit. This mechanism is recognized as an efficient step in the host antiviral response.
Langland, Jeffrey O, Jacobs, Bertram L
openaire +3 more sources
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene [PDF]
Journal of Virology, 1995 The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought to be involved in the IFN-resistant phenotype of VV. The E3L gene products, p25 and p20, act as inhibitors of PKR, presumably by binding and sequestering activator dsRNA from the ...
E, Beattie +5 more
openaire +2 more sources
Journal of Lipid Research, 2013 Bile acid sequestrants (BASs) are cholesterol-lowering drugs that also affect hyperglycemia. The mechanism by which BASs exert these and other metabolic effects beyond cholesterol lowering remains poorly understood. The present study aimed to investigate
Kanami Sugimoto-Kawabata +9 more
doaj +1 more source
PLoS ONE, 2015 As a group, poxviruses have been shown to infect a wide variety of animal species. However, there is individual variability in the range of species able to be productively infected.
Erin S Hand +4 more
doaj +1 more source
The Ebola virus VP35 protein is a suppressor of RNA silencing. [PDF]
PLoS Pathogens, 2007 RNA silencing or interference (RNAi) is a gene regulation mechanism in eukaryotes that controls cell differentiation and developmental processes via expression of microRNAs.
Joost Haasnoot +5 more
doaj +1 more source
Vaccinia virus E3 protein prevents the antiviral action of ISG15. [PDF]
PLoS Pathogens, 2008 The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense ...
Susana Guerra +4 more
doaj +1 more source