Results 61 to 70 of about 1,772 (177)

The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response

Virology, 2005
Encephalitis is a rare, but serious complication from vaccination against smallpox using replication competent strains of vaccinia virus. In this report we describe mutants of vaccinia virus, containing N-terminal deletions of the vaccinia virus interferon resistance gene, E3L, that are attenuated for neuropathogenesis in a mouse model system.
Brandt, Teresa, Heck, Michael C., Vijaysri, Sangeetha, Jentarra, Garilyn M., Cameron, Jason M., Jacobs, Bertram L.   +5 more
openaire   +2 more sources

Biological function of the vaccinia virus Z-DNA-binding protein E3L: Gene transactivation and antiapoptotic activity in HeLa cells [PDF]

Proceedings of the National Academy of Sciences, 2005
The vaccinia virus (VV) E3L protein is essential for virulence and has anti-apoptotic activity. In mice, Z-DNA-binding activity of the N-terminal domain of E3L (Zα) is necessary for viral lethality. Here, we report that inhibition of hygromycin-B-induced apoptosis in HeLa cells depends on Z-DNA binding of the E3L Zα domain.
Jin-Ah, Kwon, Alexander, Rich
openaire   +2 more sources

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice [PDF]

, 2008
Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity.
Hoogt, C.C. van der, Jukema, J.W., Haan, W. de, Hoekstra, M., Westerterp, M., Princen, H.M.G., Romijn, J.A., Rensen, P.C.N., Dallinga-Thie, G.M., Havekes, L.M.   +9 more
core   +2 more sources

Scientific Opinion on the efficacy of Suilectin TM (Phaseolus vulgaris lectins) as a zootechnical additive for suckling piglets (performance enhancer)

EFSA Journal, 2015
SuilectinTM is a preparation of Phaseolus vulgaris (kidney bean) lectins which contains a mixture of five phytohaemagglutinin (PHA) isoforms: PHA‐E4, PHA‐E3L, PHA‐E2L2, PHA‐EL3 and PHA‐L4.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Expression of the E3L Gene of Vaccinia Virus in Transgenic Mice Decreases Host Resistance to Vaccinia Virus and Leishmania major Infections [PDF]

Journal of Virology, 2008
ABSTRACT The E3L gene of vaccinia virus (VACV) encodes the E3 protein that in cultured cells inhibits the activation of interferon (IFN)-induced proteins, double-stranded RNA-dependent protein kinase (PKR), 2′-5′-oligoadenylate synthetase/RNase L (2-5A system) and adenosine deaminase (ADAR-1), thus helping the virus to evade host
Elena, Domingo-Gil, Eva, Pérez-Jiménez, Iván, Ventoso, José L, Nájera, Mariano, Esteban   +4 more
openaire   +2 more sources

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 2, Page 236-246, April 2026.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Comparison of the dsRNA interaction domain of SQPV_025, VACV_Cop E3L, human protein kinase R (PKR) and related proteins from other poxviruses.

, 2014
Conserved residues with the human form are indicated by a grey background. Asterisks above the alignment indicate those residues that have been shown to be necessary for dsRNA binding in E3L [7].
Karina Hansen Kjær (591287), Pia Møller Martensen (591289), Alistair C. Darby (210874), Colin J. McInnes (506739), Ann R. Wood (591288), Margaret Hughes (228933), Alan D. Radford (591290), Neil Hall (12782), Julian Chantrey (70799)   +8 more
core   +1 more source

Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3 [PDF]

, 2013
Zalpha domains are a subfamily of the winged helix-turn-helix domains sharing the unique ability to recognize CpG repeats in the left-handed Z-DNA conformation.
A. R. Tomé, S. Correia, Zacarias, Sónia, R. M. E. Parkhouse, L. M. Paulo, Tomé, Ana Rita, K. Kuś, Athanasiadis, Alekos, Figueiredo, Delio, Kuś, Krzysztof, M. de Rosa, Paulo, Lara Martins, A. Athanasiadis, Correia, Silvia, D. Figueiredo, Parkhouse, R Michael E, S. Zacarias, de Rosa, Matteo   +17 more
core   +1 more source

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. [PDF]

Proceedings of the National Academy of Sciences, 1992
A vaccinia virus-encoded double-stranded RNA-binding protein, p25, has been previously implicated in inhibition of the interferon-induced, double-stranded RNA-activated protein kinase. In this study, we have identified the vaccinia viral gene (WR strain) that encodes p25.
H W, Chang, J C, Watson, B L, Jacobs
openaire   +2 more sources