Results 71 to 80 of about 1,772 (177)

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanismss⃞

Journal of Lipid Research, 2009
The aim of this study was to define the anti-atherosclerotic role of liver-X-receptors (LXRs) under lesion progressive and lesion regressive conditions, to establish a temporal line of events, and to gain insights into the mechanisms underlying the anti ...
Lars Verschuren, Jitske de Vries-van der Weij, Susanne Zadelaar, Robert Kleemann, Teake Kooistra   +4 more
doaj   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Characterization of DNA-binding activity of Zα domains from poxviruses and the importance of the β-wing regions in converting B-DNA to Z-DNA [PDF]

, 2007
The E3L gene is essential for pathogenesis in vaccinia virus. The E3L gene product consists of an N-terminal Zα domain and a C-terminal double-stranded RNA (dsRNA) binding domain; the left-handed Z-DNA-binding activity of the Zα domain of E3L is required
Rich, Alexander, Kim, Kyeong Kyu, Kim, Yang-Gyun, Ha, Sung Chul, Lowenhaupt, Ky, Quyen, Dong Van   +5 more
core   +1 more source

Sedimentary Environment and Organic Matter Enrichment Model of Saline Lake Source Rock in the Linhe Depression, Hetao Basin, China

, 2023
The well-developed mudstone and gypsum mudstone in the Oligocene Linhe Formation (E3l) in the Hetao Basin are the main source rocks for gypsum. However, the sedimentary environment and organic matter (OM) enrichment factors of E3l are not clear, and this
Xiaoyan Fu, Shijia Chen, Ranran Zhou, Man Yuan, Jungang Lu, Yulei Shi   +5 more
core   +1 more source

Rapid, seamless generation of recombinant poxviruses using host range and visual selection [PDF]

, 2020
Vaccinia virus (VACV) was instrumental in eradicating variola virus (VARV), the causative agent of smallpox, from nature. Since its first use as a vaccine, VACV has been developed as a vector for therapeutic vaccines and as an oncolytic virus.
Vipat, Sameera, Haller, Sherry L, Rothenburg, Stefan, Park, Chorong, Brennan, Greg   +4 more
core   +1 more source

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.

PLoS Pathogens, 2016
Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection.
Alissa M Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J Marié, David E Levy   +5 more
doaj   +1 more source

Vaccinia Virus E3L Interferon Resistance Protein Inhibits the Interferon-Induced Adenosine Deaminase A-to-I Editing Activity

Virology, 2001
The RNA-specific adenosine deaminase (ADAR1) is an interferon-inducible editing enzyme that converts adenosine to inosine. ADAR1 contains three distinct domains: a N-terminal Z-DNA binding domain that includes two Z-DNA binding motifs; a central double-stranded RNA binding domain that includes three dsRNA binding motifs (dsRBM); and a C-terminal ...
Liu, Yong, Wolff, Karen C., Jacobs, Bertram L., Samuel, Charles E.   +3 more
openaire   +2 more sources

Incidence Rate of Otitis Externa Episodes in Atopic Dogs Is Reduced by a Therapeutic Diet in a 6‐Month Randomised, Blinded, Controlled, Clinical Trial

Veterinary Dermatology, Volume 37, Issue 1, Page 89-102, February 2026.
ABSTRACT Background Recurrent otitis externa (OE) episodes commonly affect dogs with canine atopic dermatitis (cAD) despite ongoing cAD treatment. Objective To determine if a therapeutic diet with active ingredients targeting the skin barrier and allergy pathways reduces the incidence rate of OE.
Adrian Watson, Jeremy Laxalde, Franco Martini, Nina Fischer, Elisa Maina, Claude Favrot   +5 more
wiley   +1 more source