Results 91 to 100 of about 1,772 (177)

Growth of VACVΔE3LΔK3L is restored in RK13 cells expressing VACV E3 and K3 proteins.

, 2015
(A) VACVΔE3LΔK3L was constructed using homologous recombination techniques and engineered to express GFP in place of the E3L gene. No plaque formation was visualized in wild-type RK13 cells whereas replication capacity was restored in RK13 cells stably ...
Stefan Rothenburg (66518), Adam R. Hersperger (248240), Chen Peng (429537), Sherry L. Haller (697207), Erin S. Hand (697206)   +4 more
core   +1 more source

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-Leiden/human C-reactive protein transgenic mice

, 2005
Objective - C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis.
Jukema, J.W., Szalai, A.J., Offerman, E.H., Emeis, J.J., Maas, M.C., Princen, H.M.G., Trion, A., Laarse, A. van der, Havekes, L.M., Maat, M.P.M. de   +9 more
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Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice

, 2009
Objective: Cholesteryl ester transfer protein (CETP) adversely affects the plasma lipoprotein profile by increasing VLDL-cholesterol and decreasing HDL-cholesterol.
Zadelaar, A.S.M., Kooistra, T., Toet, K., Rensen, P.C.N., Vries-van der Weij, J. de, Havekes, L.M.   +5 more
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Anti-PKR mechanisms can be exchanged between viruses.

, 2013
A) Previous infection with some viruses prevented eIF2α phosphorylation after SINV virus superinfection. The protocol followed for mixed infections is outlined. Wild type MEFs were infected with the indicated viruses at a moi of 2 pfu/cell.
José Luis Nájera (5649529), Mariano Esteban (50256), Elena Domingo-Gil (356529), René Toribio (356530), Iván Ventoso (125168)   +4 more
core   +1 more source

Research on substances with activity against orthopoxviruses

Annals of Agricultural and Environmental Medicine, 2013
Although smallpox was eradicated over 30 years ago, the disease remains a major threat. High mortality, high infectivity and low resistance of the contemporary population make the smallpox virus very attractive to terrorists.
Marcin Kołodziej, Justyna Joniec, Michał Bartoszcze, Romuald Gryko, Janusz Kocik, Józef Knap, Wioletta Żukiewicz-Sobczak, Sławomir Pancewicz, Anna Grzywacz   +8 more
doaj  

Regulation of the innate immune system [PDF]

, 2015
The innate immune system is the first line of defence against pathogen invasion. The range of diseases that are caused by deficiencies in or deregulation of the innate immune system illustrates the importance of maintaining an effective balance ...
McGlasson, Sarah Louise
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Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

, 1999
Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the APOE3Leiden gene develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis.
Gorp, P.J.J. van, Hofker, M.H., Suzuki, H., Dijk, K.W. van, Gijbels, M.J.J., Frants, R.R., Kodama, T., Havekes, L.M., Winther, M.P.J. de   +8 more
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Divergence in poxvirus-encoded E3-like proteins can dictate poxvirus activation of cellular necroptosis. [PDF]

J Virol
Enow JA, Munig S, Sample ML, Speyer G, Hundekar RC, Williams J, Bonner J, Li Y, McFadden G, Jacobs B, Rahman MM.   +10 more
europepmc   +1 more source

Targeting β2-Adrenergic Receptor Stability With Lycorine Reveals a Host-Directed Pathway for Antiviral Defense Against Poxviruses. [PDF]

Adv Sci (Weinh)
Zhang X, Xu S, Zhang Z, Wan C, Wang X, Wang P, Yang H, Huang T, Yuan Y, Atique F, Yang R, He Y, Liu Z.   +12 more
europepmc   +1 more source

Molecular Cloning of Reovirus a3 Vaccinia E3L

, 2001
v, 39 p.Preliminary data by Imani and colleagues support the hypothesis that viral infection commonly associated with asthma exacerbation leads to the formation of double-stranded RNA (ds-RNA) which induces pro inflammatory cytokines.
Khlyavich, Eve
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