Results 1 to 10 of about 30,951 (226)
The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer. [PDF]
PLoS ONE, 2011 In this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated PKR (p-PKR) and phosphorylated eIF2α (p-eIF2α).We determined the ...
Yong He +11 more
doaj +3 more sources
Insights into molecular mechanisms of poxvirus evolution and host range through studies of poxvirus inhibitors of protein kinase R [PDF]
Journal of VirologyProtein kinase R (PKR) acts both as a sensor for virus infections, by detecting double-stranded (ds) RNA, and as an antiviral effector by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Stefan Rothenburg +3 more
doaj +2 more sources
dsRNA-Dependent Protein Kinase PKR and Its Role in Stress, Signaling and HCV Infection
Viruses, 2012 The double-stranded RNA-dependent protein kinase PKR plays multiple roles in cells, in response to different stress situations. As a member of the interferon (IFN)‑Stimulated Genes, PKR was initially recognized as an actor in the antiviral action of IFN,
Eliane F Meurs, Stephanie Dabo
exaly +3 more sources
nc886 noncoding RNA regulates hepatitis B virus replication via PKR-dependent eIF2α phosphorylation [PDF]
Frontiers in Cellular and Infection MicrobiologyObjective(s)Hepatitis B virus (HBV) replication is tightly controlled by host stress and innate immune pathways. The small noncoding RNA nc886 (vtRNA2-1) is a known endogenous inhibitor of protein kinase R (PKR), but its role in HBV biology remains ...
Zahra Zahid Piracha +2 more
doaj +2 more sources
அணி இலக்கணத்தின் தாய் உவமை அணி - ஓர்ஆய்வு / A Study on Metaphor as the Mother of all Figures of Speech [PDF]
Chenkaantal, 2022 Figures of Speech illustrates the nature of the subject. It induces the imaginative and aesthetic sense of the literary work, particularly poetry. Simile is one of the figures of speech and has been used in a literary work to convey the meaning by ...
இரா. அருணா / R. Aruna
doaj +1 more source
Target Misfolded Protein Clearance Pathway for Cancer Therapy
Proceedings, 2020 The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting ...
Apar Pataer
doaj +1 more source
Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin. [PDF]
PLoS ONE, 2012 It has been reported that the expression and activity of the interferon-inducible, dsRNA-dependent protein kinase, PKR, is increased in mammary carcinoma cell lines and primary tumor samples.
Richard L Bennett +5 more
doaj +1 more source
Cells, 2020 Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation.
Erlinda The +6 more
doaj +1 more source
Journal of Orthopaedic Surgery, 2022 Background Despite the established advantages of partial knee replacements (PKR), their usage remains limited. We investigated the effect of hospital knee arthroplasty (KA) volume and the availability of a frequently used PKR by the total KA supplier on ...
Iris Koenraadt-van Oost +5 more
doaj +1 more source
Neurobiology of Disease, 2020 Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation ...
Samuel B. Burnett +4 more
doaj +1 more source