Results 31 to 40 of about 30,951 (226)
PKR deficiency alleviates pulmonary hypertension via inducing inflammasome adaptor ASC inactivation
Pulmonary Circulation, 2021 Pulmonary hypertension is a progressive fatal disease that currently has no specific therapeutic approaches. In this study, dsRNA‐dependent protein kinase (PKR) was considered a candidate molecule in pulmonary hypertension.
Yapei Li +5 more
doaj +1 more source
PKR involvement in Alzheimer’s disease [PDF]
Alzheimer's Research & Therapy, 2017 Brain lesions in Alzheimer's disease (AD) are characterized by Aβ accumulation, neurofibrillary tangles, and synaptic and neuronal vanishing. According to the amyloid cascade hypothesis, Aβ1-42 oligomers could trigger a neurotoxic cascade with kinase activation that leads to tau phosphorylation and neurodegeneration.
Hugon, Jacques +3 more
openaire +5 more sources
BMC Biology, 2008 Background Double-stranded (ds) RNA, generated during viral infection, binds and activates the mammalian anti-viral protein kinase PKR, which phosphorylates the translation initiation factor eIF2α leading to the general inhibition of protein synthesis ...
Dever Thomas E +4 more
doaj +1 more source
Mechanism of PKR Activation by dsRNA [PDF]
Journal of Molecular Biology, 2008 Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway. Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation reactions that activate the kinase. PKR then phosphorylates eukaryotic initiation factor 2alpha, thus inhibiting protein synthesis in virally infected cells.
Peter A, Lemaire +3 more
openaire +2 more sources
PLoS ONE, 2013 Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC). However, the precise roles of PKR in HCC with HCV infection remain unclear.
Takao Watanabe +8 more
doaj +1 more source
The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication [PDF]
Retrovirology, 2013 Abstract Background HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2 (eIF2α), which decreases viral replication.
Clerzius, G +10 more
openaire +2 more sources
PLoS Pathogens, 2013 PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(-/-) mice infected with T. gondii exhibited higher parasite load and worsened
Pauline Sebby Ogolla +6 more
doaj +1 more source
Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase. [PDF]
PLoS Pathogens, 2016 Activated protein kinase R (PKR) plays a vital role in antiviral defense primarily by inhibiting protein synthesis and augmenting interferon responses. Many viral proteins have adopted unique strategies to counteract the deleterious effects of PKR.
Rajini Mudhasani +5 more
doaj +1 more source
Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R
Viruses, 2022 Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman +3 more
doaj +1 more source